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      Epidemiological and genetic characteristics of porcine reproduction and respiratory syndrome virus 2 in mainland China, 2017-2018.

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          Abstract

          Porcine reproductive and respiratory syndrome virus 2 (PRRSV2) is a major threat to the global pig industry, particularly in China, the world's largest pig-rearing and pork-production country. Continuously monitoring the epidemiological and genetic characteristics of PRRSV epidemic strains is beneficial for prevention and control of infection. Previously, we reported the epidemiological and genetic characteristics of PRRSV2 in China from 2012 to 2016. Here, the epidemiological and genetic characteristics of PRRSV2 in China from 2017 to 2018 are reported. During these two years, we collected different types of porcine samples from 2428 pig farms in 27 provinces in China. Of the 7980 samples collected, 2080 (26.07%) were positive for PRRSV2 ORF5 by RT-PCR. The positive rate of PRRSV detection between different regions of China ranged from 8.12% to 29.33%, and from 7.96% to 55.50% between different months. Phylogenetic analysis based on the ORF5 gene revealed that the PRRSV2 strains currently circulating in China belong to five clades, and most of the PRRSVs detected are highly pathogenic PRRSVs (HP-PRRSVs; clade IV) and PRRSV NADC30-like strains (clade I). Sequence analysis revealed multiple amino acid mutation types, including amino acid changes and deletions in both the GP5 and Nsp2 proteins. The presence of these mutations may have an effect on the evolution of the virus by altering the viral titer and/or affecting the antibody response against the virus.

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          Author and article information

          Journal
          Arch Virol
          Archives of virology
          Springer Science and Business Media LLC
          1432-8798
          0304-8608
          Jul 2020
          : 165
          : 7
          Affiliations
          [1 ] State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China.
          [2 ] The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China.
          [3 ] Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture), Animal Husbandry and Veterinary Institute, Hubei Academy of Agricultural Sciences, Wuhan, 430070, China.
          [4 ] State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. pengzhong525@163.com.
          [5 ] The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China. pengzhong525@163.com.
          [6 ] State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China. wub@mail.hzau.edu.cn.
          [7 ] The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China. wub@mail.hzau.edu.cn.
          Article
          10.1007/s00705-020-04661-z
          10.1007/s00705-020-04661-z
          32409873
          8c2d32fc-c04b-48ec-a4af-d7d47b69eabe
          History

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