Evaluation of combined effect of hyperthermia and ionizing radiation on cytotoxic damages induced by IUdR-loaded PCL-PEG-coated magnetic nanoparticles in spheroid culture of U87MG glioblastoma cell line.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Glioblastoma multiform (GBM) is the most prevalent and aggressive type of primary brain tumor. None of the current conventional treatment methods has improved treatment considerably. Therefore, in this study the effect of magnetic nanoparticles coated with poly (caprolactone)-poly (ethylene glycol) (PCL-PEG) as a 5-iodo 2'deoxyuridine (IUdR) carrier in the presence of hyperthermia and 6 MV (megavoltage) X-ray radiation, were investigated in a spheroid model of U87MG glioblastoma cell line using colony formation assay.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Int J Radiat Biol

Title: International journal of radiation biology

Publisher: Informa UK Limited

ISSN (Electronic): 1362-3095

ISSN (Print): 0955-3002

Publication date (Electronic): November 2018

Volume: 94

Issue: 11

Affiliations

[1 ] a Department of Medical Physics School of Medicine , Iran University of Medical Sciences , Tehran , Iran.

[2 ] b Razi Drug Research Centre , Iran University of Medical Sciences , Tehran , Iran.

[3 ] c Department of Polymer Chemistry School of Sciences , University of Tehran , Tehran , Iran.

Article

DOI: 10.1080/09553002.2018.1495855

PubMed ID: 29985733

SO-VID: 8c6c8972-9025-43e9-be01-4e3c132d381c

History

Keywords: PEG-PCL,hyperthermia,iododeoxyuridine,ionizing radiation,spheroid

Data availability:

Keywords: PEG-PCL, hyperthermia, iododeoxyuridine, ionizing radiation, spheroid

Comments

Comment on this article

scite_

Cited by 8

See all cited by