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      MicroRNA-181a Inhibits Tumor Proliferation, Invasiveness, and Metastasis and Is Downregulated in Gastric Cancer

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          Abstract

          MicroRNAs (miRNAs) play crucial roles in the development and progression of human cancers, including gastric cancer. The discovery of miRNAs may provide a new and powerful tool for studying the mechanism, diagnosis, and treatment of gastric cancer. Here we show that miR-181a levels were significantly downregulated in gastric cancer tissues compared with the adjacent normal regions in 80 paired samples. Moreover, the lower levels of miR-181a were associated with the pM or pTNM stage in clinical gastric cancer patients. In addition, the ectopic expression of miR-181a in the gastric cancer cell line HGC-27 inhibited cell proliferation, cell migration, and invasion by directly interacting with the mRNA encoding the oncogenic factor Prox1. Taken together, our results indicate that miR-181a might act as a tumor suppressor in gastric cancer, which may provide a novel diagnostic and therapeutic option for human gastric cancer in the near future.

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          The long and short of microRNA.

          Luke Yates, Chris Norbury, Robert Gilbert (2013)
          MicroRNAs (miRNAs) are versatile regulators of gene expression in higher eukaryotes. In order to silence many different mRNAs in a precise manner, miRNA stability and efficacy is controlled by highly developed regulatory pathways and fine-tuning mechanisms both affecting miRNA processing and altering mature miRNA target specificity. Copyright © 2013 Elsevier Inc. All rights reserved.
          Article 0 comments Cited 266 times – based on 0 reviews     Review now
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            hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells.

            Rui-Juan Li, Peng Zhao, Johnathan Cheng … (2008)
            MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression by cleaving or repressing the translation of target mRNAs. In mammal animals, their function mainly represses the target mRNAs transcripts via imperfectly complementary to the 3' UTR of target mRNAs. Several miRNAs have been recently reported to be involved in modulation of glioma development, especially some up-regulated miRNA, such as hsa-miR-21 and hsa-miR-221. However, here we reported that the down-regulated hsa-miR-181a and hsa-miR-181b of hsa-miR-181 family were also involved in oncogenesis of glioma. Our studies showed that hsa-miR-181a and hsa-miR-181b functioned as tumor suppressors which triggered growth inhibition, induced apoptosis and inhibited invasion in glioma cells. Furthermore, the tumor-suppressive effect of hsa-miR-181b in glioma cells was more apparent than the effect of hsa-miR-181a. These findings suggest aberrantly down-regulated hsa-miR-181a and hsa-miR-181b may be critical factors that contribute to malignant appearance in human gliomas.
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              microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity.

              Vijay Chandrasekar, Jean-Luc Dreyer (2009)
              MicroRNAs play key regulatory roles in cellular processes including neurogenesis, synapse development and plasticity in the brain. Psychostimulants induce strong neuroadaptive changes through a surfeit of gene regulatory mechanisms leading to addiction. MicroRNA profiling for identifying miRNAs regulating cocaine-induced, plasticity-related genes revealed significant regulation of a set of miRNAs upon cocaine administration, especially let-7d, miR-181a and the brain-specific miR-124. These miRNAs target many genes involved in cocaine addiction. Precursor and mature miRNA quantification by qRT-PCR showed that miR-124 and let-7d are significantly downregulated, whereas miR-181a is induced in the mesolimbic dopaminergic system under chronic cocaine administration. Results were confirmed by in situ hybridization, Northern blots, FISH analysis and RNase protection assay. Using lentiviral-mediated miRNA expression, we show a significant downregulation of BDNF and D3R both at mRNA and protein levels by miR-124 and let-7d, respectively. Our data suggest that miR-124, let-7d and miR-181a may be involved in a complex feedback loop with cocaine-responsive plasticity genes, highlighting the possibility that some miRNAs are key regulators of the reward circuit and may be implicated in addiction.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Oncol Res
                Journal ID (iso-abbrev): Oncol Res
                Journal ID (publisher-id): OR
                Title: Oncology Research
                Publisher: Cognizant Communication Corporation (Elmsford, NY )
                ISSN (Print): 0965-0407
                ISSN (Electronic): 1555-3906
                Publication date Collection: 2015
                Publication date (Electronic): 09 February 2015
                Volume: 22
                Issue: 2
                Pages: 75-84
                Affiliations
                [1] Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College , Jiangyin, Jiangsu, PR China
                Author notes
                Address correspondence to Weidong Mao, Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, PR China. Tel: +86-0510-86275861; Fax: +86-0510-86275861; E-mail: weidong_mao@ 123456163.com
                Article
                Publisher ID: OR791
                DOI: 10.3727/096504014X14024160459203
                PMC ID: 7838452
                PubMed ID: 25706394
                SO-VID: 8c6d77c0-5f94-4a82-9ddc-32fd823d09c1
                Copyright © Copyright © 2015 Cognizant Comm. Corp.
                License:

                This article is licensed under a Creative Commons Attribution-NonCommercial NoDerivatives 4.0 International License.

                History
                Page count
                Figures: 4, Tables: 1, References: 31, Pages: 10
                Categories
                Subject: Article

                Keywords: gastric cancer,mir-181a,tumor suppressor,prox1
                Data availability:
                Keywords: gastric cancer, mir-181a, tumor suppressor, prox1

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