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PET/CT comparing (68)Ga-DOTATATE and other radiopharmaceuticals and in comparison with CT/MRI for the localization of sporadic metastatic pheochromocytoma and paraganglioma.

Author(s): Ingo Janssen, Clara C Chen, Corina M Millo, Alexander Ling, David Taieb, Frank I Lin, Karen T Adams, Katherine I Wolf, Peter Herscovitch, Antonio T Fojo, Inga Buchmann, Electron Kebebew, Karel Pacak

Publication date: 2016-09-01

Journal: European Journal of Nuclear Medicine and Molecular Imaging

Publisher: Springer Nature

Keywords: Metastatic, 18F-FDG, 68Ga-DOTATATE, Paraganglioma, Pheochromocytoma

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Abstract

Pheochromocytomas/paragangliomas (PPGLs) and their metastases are tumors that predominantly express somatostatin receptor 2 (SSR2). (68)Ga-DOTA(0)-Tyr(3)-octreotate ((68)Ga-DOTATATE) is a PET radiopharmaceutical with both high and selective affinity for SSRs. The purpose of this study was to evaluate the utility of (68)Ga-DOTATATE in comparison with other specific and nonspecific radiopharmaceuticals recommended in the current guidelines for the localization of metastatic sporadic PPGL by PET/CT.

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DOI:: 10.1007/s00259-016-3357-x

PubMed ID:: 26996779

Keywords: Metastatic,18F-FDG,68Ga-DOTATATE,Paraganglioma,Pheochromocytoma

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Keywords: Metastatic, 18F-FDG, 68Ga-DOTATATE, Paraganglioma, Pheochromocytoma

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