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      Effect of Long-Term Electrical Stimulation of Rabbit Fast Muscles on the Reactivity of Their Supplying Arteries

      a , b

      Journal of Vascular Research

      S. Karger AG

      Blood flow, Noradrenaline uptake, Dose-response curve

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          Abstract

          Rabbit fast hindlimb muscle (tibialis anterior, extensor digitorum longus and peroneal muscles) were stimulated for 14 days, 8 h/day using implanted electrodes, with two different frequencies of stimulation (continuous at 10 Hz or 3 bursts/min at 40 Hz) giving the same total number of stimuli. Both patterns of stimulation resulted in a different pattern of flow and perfusion pressure, with lowered perfusion pressure during contractions in muscles stimulated at 10 Hz and intermittent increase during the peak of tetanic contractions in muscle stimulated at 40 Hz. The arteries supplying the stimulated muscle (anterior tibial artery) were then tested for reactivity to noradrenaline in vitro. Maximal tension developed by control arteries (supplying the contralateral nonstimulated muscles) was 18 ± 1.4 g/mg dry weight in response to 10<sup>-5</sup> M noradrenaline. Arteries supplying muscle stimulated at 10 Hz showed a significant increase of the maximal response (22 ± 1.5 g/mg) with the same dose. Arteries supplying muscles that had been stimulated at 40 Hz showed decreased response with maximal tension 9.1 ± 1.2 g/mg. Noradrenaline uptake and clearance showed similar values in control vessels and those stimulated at either frequency. Thus, long-term stimulation of skeletal muscles can modify the reactivity of supplying arteries; the response varied with the pattern of contractions and may be explained by a different pattern of flow changes.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1992
          1992
          23 September 2008
          : 29
          : 1
          : 13-19
          Affiliations
          aDepartment of Physiology, University of Birmingham, Medical School, Birmingham, UK; bAMES-Bioengineering, University of California, San Diego, La Jolla, Calif., USA
          Article
          158926 J Vasc Res 1992;29:13–19
          10.1159/000158926
          1554862
          © 1992 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Research Paper

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