Effect of Long-Term Electrical Stimulation of Rabbit Fast Muscles on the Reactivity of Their Supplying Arteries

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Abstract

Rabbit fast hindlimb muscle (tibialis anterior, extensor digitorum longus and peroneal muscles) were stimulated for 14 days, 8 h/day using implanted electrodes, with two different frequencies of stimulation (continuous at 10 Hz or 3 bursts/min at 40 Hz) giving the same total number of stimuli. Both patterns of stimulation resulted in a different pattern of flow and perfusion pressure, with lowered perfusion pressure during contractions in muscles stimulated at 10 Hz and intermittent increase during the peak of tetanic contractions in muscle stimulated at 40 Hz. The arteries supplying the stimulated muscle (anterior tibial artery) were then tested for reactivity to noradrenaline in vitro. Maximal tension developed by control arteries (supplying the contralateral nonstimulated muscles) was 18 ± 1.4 g/mg dry weight in response to 10<sup>-5</sup> M noradrenaline. Arteries supplying muscle stimulated at 10 Hz showed a significant increase of the maximal response (22 ± 1.5 g/mg) with the same dose. Arteries supplying muscles that had been stimulated at 40 Hz showed decreased response with maximal tension 9.1 ± 1.2 g/mg. Noradrenaline uptake and clearance showed similar values in control vessels and those stimulated at either frequency. Thus, long-term stimulation of skeletal muscles can modify the reactivity of supplying arteries; the response varied with the pattern of contractions and may be explained by a different pattern of flow changes.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 23 September 2008

Volume: 29

Issue: 1

Pages: 13-19

Affiliations

^aDepartment of Physiology, University of Birmingham, Medical School, Birmingham, UK; ^bAMES-Bioengineering, University of California, San Diego, La Jolla, Calif., USA

Article

Publisher ID: 158926 Other ID: J Vasc Res 1992;29:13–19

DOI: 10.1159/000158926

PubMed ID: 1554862

SO-VID: 8cbc4f0c-3f65-41dd-ae5a-1c34d8db2477

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 01 June 1990

Date accepted : 07 March 1991

Page count

Pages: 7

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