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The relation between depression and parkin genotype: the CORE-PD study.
A Srivastava
1 ,
M-X Tang ,
H Mejia-Santana ,
L Rosado ,
E D Louis ,
E Caccappolo ,
C Comella ,
A Colcher ,
A Siderowf ,
D Jennings ,
M Nance ,
S Bressman ,
W K Scott ,
C Tanner ,
S Mickel ,
H Andrews ,
C Waters ,
S Fahn ,
L Cote ,
S Frucht ,
B Ford ,
R N Alcalay ,
B Ross ,
M Orbe Reilly ,
M Rezak ,
K Novak ,
J H Friedman ,
R D Pfeiffer ,
L Marsh ,
B Hiner ,
D Merle ,
R Ottman ,
L N Clark ,
K Marder
Dec 2011
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Abstract
Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives.