Effect of Buspirone, Fluoxetine and 8-OH-DPAT on Striatal Expression of Bax, Caspase-3 and Bcl-2 Proteins in 6-Hydroxydopamine-Induced Hemi-Parkinsonian Rats.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The exact pathogenesis of sporadic parkinson's disease (PD) is still unclear. Numerous evidences suggest involvement of apoptosis in the death of dopaminergic neurons. In this study we investigated the effect of sub-chronic administration of buspirone, fluoxetine and 8-hydroxy-2-[di-n-propylamino]tetralin (8-OH-DPAT) in 6-hydroxydopamine (6-OHDA)-lesioned rats and assayed striatal concentrations of apoptotic (Bax, Caspase3) and anti-apoptotic (Bcl-2) proteins.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Adv Pharm Bull

Title: Advanced pharmaceutical bulletin

Publisher: International Society for Phytocosmetic Sciences

ISSN: 2228-5881

ISSN (Print): 2228-5881

Publication date (Electronic): Nov 2015

Volume: 5

Issue: 4

Affiliations

[1 ] Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

[2 ] Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

[3 ] Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

[4 ] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Hamadan University of Medical Science, Hamadan, Iran.

Article

DOI: 10.15171/apb.2015.067

PMC ID: 4729346

PubMed ID: 26819921

SO-VID: 8f09fe58-dc62-40ed-9f7e-ffa498b3b28b

History

Keywords: 8-OH-DPAT,Apoptosis,Buspirone,Fluoxetine,Parkinson's Disease

Data availability:

Keywords: 8-OH-DPAT, Apoptosis, Buspirone, Fluoxetine, Parkinson's Disease

Comments

Comment on this article

scite_

Cited by 6

See all cited by