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      Myeloid-derived suppressor cells

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      Cancer immunology research

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          Abstract

          Myeloid cells evolutionary developed as a major mechanism to protect the host. They evolved as a critical barrier against infections and are important contributors to tissue remodeling. However, in cancer, myeloid cells are largely converted to serve a new master – tumor cells. This process is epitomized by myeloid-derived suppressor cells (MDSC). These cells are closely related to neutrophils and monocytes. MDSC are not present at steady state in healthy individuals and appear in cancer and pathological conditions associated with chronic inflammation or stress. These cells have emerged as an important contributor to tumor progression. In recent years, ample evidence supports a key role of MDSC in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases. MDSC have a fascinating biology and are implicated in limiting the effects of cancer immunotherapy. Therefore, targeting these cells may represent an attractive therapeutic opportunity.

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          Author and article information

          Contributors
          Journal
          101614637
          41946
          Cancer Immunol Res
          Cancer Immunol Res
          Cancer immunology research
          2326-6066
          2326-6074
          3 April 2017
          January 2017
          01 January 2018
          : 5
          : 1
          : 3-8
          Affiliations
          The Wistar Institute, Philadelphia, PA, 19104, USA
          Author notes
          [* ]Address for correspondence: Dmitry Gabrilovich: The Wistar Institute, 3601 Spruce Str. Philadelphia, PA, 19085 dgabrilovich@ 123456wistar.org
          Article
          PMC5426480 PMC5426480 5426480 nihpa859257
          10.1158/2326-6066.CIR-16-0297
          5426480
          28052991
          8f240a96-a154-484f-93b5-9c8a398f318c
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