T cells in celiac disease

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Abstract

Celiac disease is a human T cell mediated autoimmune-like disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how a CD4 T cell responses directed against an exogenous antigen can cause an autoreactive B-cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, the review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease.

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Journal

Journal ID (nlm-journal-id): 2985117R

Journal ID (pubmed-jr-id): 4816

Journal ID (nlm-ta): J Immunol

Journal ID (iso-abbrev): J. Immunol.

Title: Journal of immunology (Baltimore, Md. : 1950)

ISSN (Print): 0022-1767

ISSN (Electronic): 1550-6606

Publication date Nihms-submitted: 27 March 2017

Publication date (Print): 15 April 2017

Publication date PMC-release: 15 April 2018

Volume: 198

Issue: 8

Pages: 3005-3014

Affiliations

[1 ]Department of Medicine, Pathology and Pediatrics, University of Chicago, Chicago, Illinois 60637, USA

[2 ]Centre for Immune Regulation and KG Jebsen Centre for Coeliac Disease Research, Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, N-0372 Oslo, Norway

Author notes

Correspondence: bjabri@ 123456bsd.uchicago.edu and l.m.sollid@ 123456medisin.uio.no

Article

Accession ID: PMC5426360 Pmcid ID: PMC5426360 Pmc-uid ID: 5426360 Manuscript ID: nihpa853736

DOI: 10.4049/jimmunol.1601693

PMC ID: 5426360

PubMed ID: 28373482

SO-VID: 905b1cd0-1fd7-4ab9-8bf4-164d8349fad7

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