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      Comparison of retinal nerve fiber layer measurements using Stratus OCT fast and regular scan protocols in eyes with band atrophy of the optic nerve and normal controls Translated title: Comparação das medidas da camada de fibras nervosas retinianas realizadas com os protocolos "fast" e "regular" do Stratus OCT em olhos com atrofia em banda do nervo óptico e controles normais

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          Abstract

          PURPOSE: To compare retinal nerve fiber layer (RNFL) measurements made with two different protocols of optical coherence tomography in eyes with band atrophy (BA) of the optic nerve and controls. METHODS: Twenty-nine eyes with BA from chiasmal compression and 30 normal eyes underwent RNFL scans using both the fast (256 A-scans) and the regular (512 A-scans) protocols. The two sets of measurements were compared. RESULTS: In eyes with BA, fast RNFL measurements were significantly greater compared with regular RNFL measurements in the superior and inferior quadrants and significantly smaller at the 30-degree segments located at the 3 and 6 o'clock meridians. In normal eyes, fast RNFL measurements of the total average, superior and inferior quadrants and the segments corresponding to the 1, 3, 4 and 12 o'clock meridians were significantly greater than regular protocol measurements. Measurements with both protocols were significantly different in eyes with BA compared to normal eyes. CONCLUSIONS: Although both fast and regular RNFL measurements were equally efficient at differentiating eyes with BA from controls the fast protocol yielded greater values in areas with thick RNFL and smaller values in areas with thin RNFL when compared with the regular scanning protocol. One should be aware of such differences when comparing measurements with both scanning protocols.

          Translated abstract

          OBJETIVO: Comparar as medidas da camada de fibras nervosas da retina (CFNR) realizada com dois protocolos de exame da tomografia de coerência óptica (TCO) em olhos com atrofia em banda (AB) do nervo óptico e controles. MÉTODOS: Vinte nove olhos com AB e 30 olhos normais foram submetidos a TCO utilizando tanto o protocolo "fast" (256 scans A) como o "regular" (512 scans A). As medidas foram comparadas. RESULTADOS: Em olhos com AB, as medidas da CFNR com o protocolo "fast" foram significativamente maiores do que aquelas do protocolo "regular" nos quadrantes superior e inferior e significativamente menores nos segmentos de 30 graus localizados nos meridianos correspondentes às 3 e 6 horas. Nos olhos normais, as medidas com o protocolo "fast" correspondentes à média global, aos quadrantes superior e inferior e aos segmentos de 30 graus correspondentes aos meridianos situados à 1, 3, 4 e 12 horas foram significativamente maiores do que aquelas do protocolo "regular". As medidas com os dois protocolos foram significativamente diferentes em olhos com AB quando comparados aos olhos normais. CONCLUSÕES: Embora as medidas obtidas tanto com o protocolo "fast" como com o "regular" tenha sido igualmente eficientes na diferenciação de olhos com AB dos normais, o protocolo "fast" forneceu valores maiores em áreas com CFNR mais espessas, e menores em áreas com CFNR mais finas quando comparados com o protocolo "regular". Deve-se estar atento a estas diferenças quando se comparam as medidas obtidas com os dois protocolos de exame.

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          Comparing the Areas under Two or More Correlated Receiver Operating Characteristic Curves: A Nonparametric Approach

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            Optical coherence tomography

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              Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography.

              Optical coherence tomography (OCT) is a new technology that uses near-infrared light in an interferometer to produce approximately 10-microns resolution cross-sectional images of the tissue of interest. The authors performed repeated quantitative assessment of nerve fiber layer thickness in individuals with normal and glaucomatous eyes, and they evaluated the reproducibility of these measurements. The authors studied 21 eyes of 21 subjects by OCT. Each subject underwent five repetitions of a series of scans on five separate occasions within a 1-month period. Each series consisted of three circular scans around the optic nerve head (diameters, 2.9, 3.4, and 4.5 mm). Each series was performed separately using internal (fixation with same eye being studied) and external (fixation with contralateral eye) fixation techniques. The eye studied and the sequence of testing were assigned randomly. Internal fixation (IF), in general, provides a slightly higher degree of reproducibility than external fixation (EF). Reproducibility was better in a given eye on a given visit than from visit to visit. Reproducibility as measured by intraclass correlation coefficients were as follows: circle diameter (CD), 2.9 mm, 0.51/0.57 (normal/glaucoma) (IF), 0.43/0.54 (EF); CD, 3.4 mm, 0.56/0.52 (IF), 0.43/0.61 (EF); CD, 4.5 mm, 0.53/0.43 (IF), 0.42/0.49 (EF). Nerve fiber layer thickness can be reproducibly measured using OCT. Internal is superior to external fixation; each circle diameter tested provides adequate reproducibility.
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                Author and article information

                Journal
                abo
                Arquivos Brasileiros de Oftalmologia
                Arq. Bras. Oftalmol.
                Conselho Brasileiro de Oftalmologia (São Paulo, SP, Brazil )
                0004-2749
                1678-2925
                August 2008
                : 71
                : 4
                : 534-539
                Affiliations
                [01] orgnameUniversity of São Paulo orgdiv1Medical School
                [02] orgnameUniversity of São Paulo orgdiv1Medical School
                [03] orgnameUniversity of São Paulo orgdiv1Medical School
                Article
                S0004-27492008000400013 S0004-2749(08)07100413
                91481a10-7298-4d9b-8205-6013a0b8cc43

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 16 March 2008
                : 02 October 2007
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 17, Pages: 6
                Product

                SciELO Brazil

                Categories
                Original Article

                Tomografia de coerência óptica,Case-control studies,Optic atrophy,Retina,Nerve fiber,Tomography, optical coherence,Estudos de casos e controles,Atrofia óptica,Fibras nervosas

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