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      Torsional Ultrasound Sensor Optimization for Soft Tissue Characterization

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          Abstract

          Torsion mechanical waves have the capability to characterize shear stiffness moduli of soft tissue. Under this hypothesis, a computational methodology is proposed to design and optimize a piezoelectrics-based transmitter and receiver to generate and measure the response of torsional ultrasonic waves. The procedure employed is divided into two steps: (i) a finite element method (FEM) is developed to obtain a transmitted and received waveform as well as a resonance frequency of a previous geometry validated with a semi-analytical simplified model and (ii) a probabilistic optimality criteria of the design based on inverse problem from the estimation of robust probability of detection (RPOD) to maximize the detection of the pathology defined in terms of changes of shear stiffness. This study collects different options of design in two separated models, in transmission and contact, respectively. The main contribution of this work describes a framework to establish such as forward, inverse and optimization procedures to choose a set of appropriate parameters of a transducer. This methodological framework may be generalizable for other different applications.

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          Most cited references46

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          Supersonic shear imaging: a new technique for soft tissue elasticity mapping

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            Genetic algorithms in search, optimization, and machine learning

            (1989)
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              Medical ultrasound: imaging of soft tissue strain and elasticity.

              After X-radiography, ultrasound is now the most common of all the medical imaging technologies. For millennia, manual palpation has been used to assist in diagnosis, but it is subjective and restricted to larger and more superficial structures. Following an introduction to the subject of elasticity, the elasticity of biological soft tissues is discussed and published data are presented. The basic physical principles of pulse-echo and Doppler ultrasonic techniques are explained. The history of ultrasonic imaging of soft tissue strain and elasticity is summarized, together with a brief critique of previously published reviews. The relevant techniques-low-frequency vibration, step, freehand and physiological displacement, and radiation force (displacement, impulse, shear wave and acoustic emission)-are described. Tissue-mimicking materials are indispensible for the assessment of these techniques and their characteristics are reported. Emerging clinical applications in breast disease, cardiology, dermatology, gastroenterology, gynaecology, minimally invasive surgery, musculoskeletal studies, radiotherapy, tissue engineering, urology and vascular disease are critically discussed. It is concluded that ultrasonic imaging of soft tissue strain and elasticity is now sufficiently well developed to have clinical utility. The potential for further research is examined and it is anticipated that the technology will become a powerful mainstream investigative tool.
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                Author and article information

                Journal
                Sensors (Basel)
                Sensors (Basel)
                sensors
                Sensors (Basel, Switzerland)
                MDPI
                1424-8220
                15 June 2017
                June 2017
                : 17
                : 6
                : 1402
                Affiliations
                Department of Structural Mechanics, University of Granada; ETS Ingenieros de Caminos, Severo Ochoa s/n, 18071 Granada, Spain; rmb@ 123456ugr.es (R.M.); grus@ 123456ugr.es (G.R.)
                Author notes
                [* ]Correspondence: jmelchor@ 123456ugr.es ; Tel.: +34-958-240-037
                Article
                sensors-17-01402
                10.3390/s17061402
                5492724
                28617353
                91aa7c4c-841e-4f0a-9288-499e7db601eb
                © 2017 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 02 May 2017
                : 09 June 2017
                Categories
                Article

                Biomedical engineering
                torsional ultrasound,probability of detection,soft tissue mechanics,finite element method,optimization,inverse problem

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