Self-report and dry blood spot measurement of antiretroviral medications as markers of adherence in pregnant women in rural South Africa

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Abstract

Antiretroviral (ARV) adherence is essential to prevent mother-to-child transmission of HIV. This study compared self-reported adherence versus ARV detection in dried blood spots (DBS) among N=392 HIV-infected pregnant women in South Africa (SA). Women completed two self-reported adherence measures [Visual Analog Scale (VAS), AIDS Clinical Trials Group Adherence (ACTG)]. Adherence was 89% (VAS), 80% (ACTG), and 74% (DBS). Self-report measures marginally agreed with DBS (VAS: Kappa=0.101, Area Under the ROC Curve (AUROC)=0.543; ACTG: Kappa=0.081, AUROC=0.538). Self-reported adherence was overestimated and agreement with DBS was poor. Validation of self-reported ARV adherence among pregnant HIV+ women in SA is needed.

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Author and article information

Journal

Journal ID (nlm-journal-id): 9712133

Journal ID (pubmed-jr-id): 21042

Journal ID (nlm-ta): AIDS Behav

Journal ID (iso-abbrev): AIDS Behav

Title: AIDS and behavior

ISSN (Print): 1090-7165

ISSN (Electronic): 1573-3254

Publication date Nihms-submitted: 30 March 2017

Publication date (Print): July 2017

Publication date PMC-release: 01 July 2018

Volume: 21

Issue: 7

Pages: 2135-2140

Affiliations

[1 ]Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida

[2 ]HIV/AIDS/STIs and TB (HAST) Research Programme, Human Sciences Research Council, Pretoria, South Africa

[3 ]Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida

[4 ]Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California

[5 ]ASEAN Institute for Health Development, Mahidol University, Salaya, Thailand

[6 ]Department of Research & Innovation, University of Limpopo, Sovenga, South Africa

Author notes

Corresponding Author: Maria L Alcaide, MD, Associate Professor of Clinical Medicine, Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine. Address: 1120 NW 14 Street, Miami, Fl. 33136 CRB 864 (D-90A). Telephone: (305) 243-8434. MAlcaide@ 123456med.miami.edu

Article

Accession ID: PMC5493507 Pmcid ID: PMC5493507 Pmc-uid ID: 5493507 Manuscript ID: nihpa864313

DOI: 10.1007/s10461-017-1760-3

PMC ID: 5493507

PubMed ID: 28361454

SO-VID: 92e53ade-830a-4bf1-96b9-2d6356e0c4d7

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