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      Rôle de la radiothérapie dans le traitement de l'améloblastome: à propos de deux cas Translated title: Role of radiotherapy in the treatment of ameloblastoma: report of two cases


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          L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Le rôle de la radiothérapie dans son traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L’évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans.

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          The purpose of this article is to review the pertinent literature and discuss the optimal treatment and outcomes for patients with ameloblastoma. Ameloblastoma is an uncommon benign, locally aggressive odontogenic neoplasm that usually occurs in the vicinity of the mandibular molars or ramus. Uncontrolled, ameloblastoma may cause significant morbidity and occasionally death. The median age is approximately 35 years and males and females are equally affected. The majority of ameloblastomas are multicystic, which are more difficult to eradicate than the unicystic and peripheral varieties. Although surgery is the mainstay of treatment, the extent of resection is controversial. Radical resections, including marginal and segmental mandibulectomy, result in local control rates exceeding 90%. In contrast, conservative procedures such as enucleation and/or curettage result in local control rates of approximately 80% and 50% for unicystic and multicystic ameloblastomas, respectively. Limited experience with radiotherapy indicates that it may reduce the risk of progression and result in long-term local control in the occasional patient with incompletely resectable disease. The optimal treatment for ameloblastoma is wide en bloc resection. Radiotherapy may improve the likelihood of local control in the occasional patient with incompletely resectable tumor.
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            Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation.

            Ten patients with ameloblastoma of the jaw were treated with megavoltage irradiation between 1958 and 1982. Seven cases were treated with radiation alone and six responded initially. One patient subsequently recurred and was successfully salvaged surgically. Three patients were treated with combined radiation therapy and surgery. Carefully applied megavoltage irradiation has a useful role in the management of ameloblastoma, particularly in large maxillary tumors with associated destruction of the infrastructure of the maxillary antrum. It is apparent from this series, and from the literature, that the ameloblastoma is not an inherently radioresistant tumor.
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              Ameloblastoma of the jaw. Treatment with radiation therapy and a case report.

              Ameloblastoma of the jaw is an aggressive benign tumor of epithelial origin that has generally been treated surgically even for metastases. This article is a review of the literature and a report of a previously unpublished case. Despite earlier reports, it is suggested that the available data clearly indicate that it is a radiosensitive tumor. In this report, specific recommendations for radiation therapy are outlined, and guidelines for treatment planning, radiation dosage, and fractionation expected outcome and follow-up are given.

                Author and article information

                Pan Afr Med J
                Pan Afr Med J
                The Pan African Medical Journal
                The African Field Epidemiology Network
                26 September 2014
                : 19
                [1 ]Service de Radiothérapie, CHU Hassan II, Fès, Maroc
                [2 ]Service de Radiothérapie, Institut national d'Oncologie, Rabat, Maroc
                [3 ]Service d'Anatomie Pathologique, CHU Hassan II, Fès, Maroc
                Author notes
                [& ]Corresponding author: Abderrahman El Mazghi, Service de Radiothérapie CHU Hassan II, Fès, Maroc
                © Abderrahman El Mazghi et al.

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Case Report

                améloblastome,mandibule,radiothérapie,tumeur bénigne,ameloblastoma,mandible,radiotherapy,benign tumor


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