Newborn telomere length predicts later life telomere length: Tracking telomere length from birth to child- and adulthood

Abstract

Background

Telomere length (TL) is considered a biological marker of aging and may indicate age-related disease susceptibility. Adults and children show a fixed ranking and tracking of TL over time. However, the contribution of an individual's initial birth TL to their later life TL is unknown. We evaluated change and tracking of TL from birth to child- and adulthood.

Methods

Telomere length at birth was measured using qPCR in two independent prospective birth cohorts. After a median follow-up period of 4 years in ENVIR ONAGE ( n = 273) we assessed leukocyte telomere length (LTL) and after 23 years in EFPTS ( n = 164) buccal TL was assessed. Correlations and multivariable regression models were applied to study telomere tracking and determinants of TL change from birth onwards.

Findings

In children, LTL at the age of 4 correlates with TL at the start of life both in cord blood ( r = 0.71, P < 0.0001;) and placenta ( r = 0.60, P < 0.0001) and was –11.2% and –33.1% shorter, respectively. In adulthood, buccal TL at the age of 23 correlates with placental TL ( r = 0.46, P < 0.0001) and was –35.9% shorter. TL attrition was higher in individuals with longer birth TL. However, based on TL ranking, individuals do not tend to change dramatically from TL rank after 4 or 23 years of follow-up. Finally, longer maternal TL associates with lower telomere attrition in the next generation.

Interpretation

The high prediction of newborn TL for later life TL, and stable TL ranking from birth onwards underscores the importance of understanding the initial setting of newborn TL and its significance for later life.

Funding

European Research Council (ERC-StG310898) and Flemish Scientific Fund (12X9620N).