Fractures in healthy females followed from childhood to early adulthood are associated with later menarcheal age and with impaired bone microstructure at peak bone mass.

Abstract

Whether fractures observed in healthy children are associated with microstructural alterations and strength deficit that persists by the end of the growth period is not established. Considering the importance of pubertal timing in bone development, we also quantified the fracture risk related to later menarcheal age (MENA).