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Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
January 01 1993
January 01 1993
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Abstract
<p class="first" id="d6668241e65">Tumor necrosis factor-alpha (TNF-alpha) has been
shown to have certain catabolic effects
on fat cells and whole animals. An induction of TNF-alpha messenger RNA expression
was observed in adipose tissue from four different rodent models of obesity and diabetes.
TNF-alpha protein was also elevated locally and systemically. Neutralization of TNF-alpha
in obese fa/fa rats caused a significant increase in the peripheral uptake of glucose
in response to insulin. These results indicate a role for TNF-alpha in obesity and
particularly in the insulin resistance and diabetes that often accompany obesity.
</p>