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      MUCOCUTANEOUS MANIFESTATIONS OF DENGUE FEVER

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      Author(s): , 1 ,
      Publication date (Print):
      Journal: Indian Journal of Dermatology
      Publisher: Medknow Publications
      Keywords: Dengue fever, mucocutaneous, rash

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          Abstract

          Dengue viral infection is a cause of considerable morbidity and mortality and may be associated with a variety of mucocutaneous manifestations that may provide important early clues to the diagnosis of this condition. Cutaneous and mucosal findings like confluent erythema, morbilliform eruptions, and hemorrhagic lesions may figure prominently in the clinical features of dengue. The differential diagnoses include a large number of bacterial and viral exanthems as well as drug rash.

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          Severe adverse cutaneous reactions to drugs.

          J C Roujeau, R S Stern (1994)
          Article 0 comments Cited 243 times – based on 0 reviews     Review now
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            Research on dengue during World War II.

            A SABIN (1952)
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              Human skin Langerhans cells are targets of dengue virus infection.

              S. Wu, G. Grouard-Vogel, W. Sun … (2000)
              Dengue virus (DV), an arthropod-borne flavivirus, causes a febrile illness for which there is no antiviral treatment and no vaccine. Macrophages are important in dengue pathogenesis; however, the initial target cell for DV infection remains unknown. As DV is introduced into human skin by mosquitoes of the genus Aedes, we undertook experiments to determine whether human dendritic cells (DCs) were permissive for the growth of DV. Initial experiments demonstrated that blood-derived DCs were 10-fold more permissive for DV infection than were monocytes or macrophages. We confirmed this with human skin DCs (Langerhans cells and dermal/interstitial DCs). Using cadaveric human skin explants, we exposed skin DCs to DV ex vivo. Of the human leukocyte antigen DR-positive DCs that migrated from the skin, emigrants from both dermis and epidermis, 60-80% expressed DV antigens. These observations were supported by histologic findings from the skin rash of a human subject who received an attenuated tetravalent dengue vaccine. Immunohistochemistry of the skin showed CD1a-positive DCs double-labeled with an antibody against DV envelope glycoprotein. These data demonstrate that human skin DCs are permissive for DV infection, and provide a potential mechanism for the transmission of DV into human skin.
              Article 0 comments Cited 146 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Dermatol
                Journal ID (publisher-id): IJD
                Title: Indian Journal of Dermatology
                Publisher: Medknow Publications (India )
                ISSN (Print): 0019-5154
                ISSN (Electronic): 1998-3611
                Publication date (Print): Jan-Mar 2010
                Volume: 55
                Issue: 1
                Pages: 79-85
                Affiliations
                From the Department of Dermatology, Christian Medical College, Ludhiana, India.
                [1 ] From the Department of Medicine, Christian Medical College, Ludhiana, India.
                Author notes
                Address for correspondence: Dr. E.A Thomas, Department. of Dermatology, Christian Medical College, Ludhiana, India. E-mail: emyabi@ 123456gmail.com
                Article
                Publisher ID: IJD-55-79
                DOI: 10.4103/0019-5154.60359
                PMC ID: 2856380
                PubMed ID: 20418984
                SO-VID: 94bf91e8-111c-4cb4-b8d1-58457cb61186
                Copyright © © Indian Journal of Dermatology
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : August 2009
                Date accepted : September 2009
                Categories
                Subject: IJD Symposium

                ScienceOpen disciplines: Dermatology
                Keywords: rash,dengue fever,mucocutaneous
                Data availability:
                ScienceOpen disciplines: Dermatology
                Keywords: rash, dengue fever, mucocutaneous

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