Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection.

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Abstract

Previously, we demonstrated that sirtuin (SIRT)1 plays vital roles in the small intestine (SI), protecting against severe hemorrhagic shock (HS), and that polydatin (PD) can attenuate SI injury via SIRT1 activation.

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Journal ID (iso-abbrev): Expert Opin. Ther. Targets

Title: Expert opinion on therapeutic targets

ISSN (Electronic): 1744-7631

ISSN (Print): 1472-8222

Publication date (Electronic): Jun 2016

Volume: 20

Issue: 6

Affiliations

[1 ] a Department of Critical Care Medicine , Nanfang Hospital, Southern Medical University , Guangzhou , P. R. China.

[2 ] b The First People's Hospital of Chenzhou, Department of Critical Care Medicine , Institute of Translational Medicine , Chenzhou , P. R. China.

[3 ] c Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology , Southern Medical University , Guangzhou , P. R. China.

Article

DOI: 10.1080/14728222.2016.1177023

PubMed ID: 27067422

SO-VID: 94e1e4f3-df98-4a68-8fa3-1a342de337e5

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Keywords: Deacetylation,SIRT3,SOD2,hemorrhagic shock,intestinal injury,mitochondrial dysfunction

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Keywords: Deacetylation, SIRT3, SOD2, hemorrhagic shock, intestinal injury, mitochondrial dysfunction

Polydatin ameliorates injury to the small intestine induced by hemorrhagic shock via SIRT3 activation-mediated mitochondrial protection.

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