5
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Pênfigo foliáceo em um eqüino Translated title: Pemphigus foliaceus in a horse

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Pênfigo foliáceo é uma rara afecção cutânea auto-imune que acomete várias espécies. Relata-se o caso de uma égua de quatro anos de idade, sem raça definida, apresentando áreas de alopecia, exsudação e crostas localizadas na face, região peitoral e membros pélvicos, além de prurido. Os exames laboratoriais para pesquisa de ácaros, bactérias e estruturas fúngicas foram negativos. O exame histopatológico revelou uma dermatite pustular intra-epidérmica com acantólise subcorneal, assim como dermatite perivascular superficial, com infiltração de eosinófilos, sendo o quadro compatível com pênfigo foliáceo.

          Translated abstract

          Pemphigus foliaceus is an uncommon autoimmune skin disorder affecting various species. A case of a 4-year-old mare of undefined breed, displaying alopecic areas, exsudation and crusty lesions on the face, breast region, and hindlimbs as well as pruritus, is reported. Laboratory exams for mite, bacteria and fungal structures were negative. Histopathological exam revealed an intra-epidermal pustule dermatitis with acantholysis, as well as superficial perisvascular dermatitis with infiltration of eosinophyles, conditions compatible with pemphigus foliaceus.

          Related collections

          Most cited references23

          • Record: found
          • Abstract: not found
          • Article: not found

          Immunologic diseases

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Gaining more insight into the pathomechanisms of thiol-induced acantholysis.

            Acantholysis is considered the initial and the main pathogenetic event of pemphigus. The first step in drug-induced acantholysis (biochemical and/or immunological) involves binding of the drug to the cell membrane and the formation of 'drug-cysteine' instead of 'cysteine-cysteine' bondings. We suggest that the reaction of D-penicillamine with cystine disulfides that results in cysteine-penicillamine disulfides is not a terminal reaction, but rather a primary initiating step of a chain reaction. It is reasonable to consider that the cysteine-penicillamine disulfide is continuing to be enzymatically reduced by various thiol reductants, in particular glutathione reductase, thereby generating a 'new' penicillamine molecule which, in turn, reacts with other cystine disulfides and does so in an unending cycle. A chain reaction is thus created in which the drug is repeatedly generated so that one molecule of the drug may attack thousands of cystine disulfide bonds. It is highly possible that normal individuals have their own endogenous means of controlling this deleterious chain reaction, whereas pemphigus-prone individuals lack the ability to stop this potentially damaging reaction. Drug-induced pemphigus should thus be added to the ever-growing list of adverse drug reactions related to pharmacogenetic disorders in drug metabolism.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The comparative pathology of non-viral bullous skin diseases in domestic animals.

              In a review of non-viral bullous skin diseases of domestic animals and a 4-year study of cases presented to the New York State College of Veterinary Medicine, we found 15 diseases: pemphigus vulgaris, pemphigus vegetans, pemphigus foliaceus, pemphigus erythematosus, bullous pemphigoid, systemic lupus erythematosus, dermatitis herpetiformis, toxic epidermal necrolysis, drug eruption, epidermolysis bullosa, epidermolysis bullosa simplex, familial acantholysis, bovine congenital porphyria, impetigo and subcorneal pustular dermatosis. The 15 diseases were placed in five categories: autoimmune, immune-mediated, hereditary, bacterial and idiopathic. A histologic classification of these disorders based on the site of blister formation and other important clinicopathologic, histologic and immunopathologic findings was developed.
                Bookmark

                Author and article information

                Journal
                cr
                Ciência Rural
                Cienc. Rural
                Universidade Federal de Santa Maria (Santa Maria, RS, Brazil )
                0103-8478
                1678-4596
                April 2007
                : 37
                : 2
                : 594-598
                Affiliations
                [02] Viçosa MG orgnameUniversidade Federal de Viçosa orgdiv1Departamento de Veterinária orgdiv2Setor de Clínica Brasil msouza@ 123456ufv.br
                [03] Viçosa MG orgnameUniversidade Federal de Viçosa Brasil
                [04] Viçosa MG orgnameUniversidade Federal de Viçosa orgdiv1Departamento de Veterinária orgdiv2Setor de epidemiologia Brasil
                [01] Viçosa MG orgnameUniversidade Federal de Viçosa orgdiv1Departamento de Veterinária Brasil
                Article
                S0103-84782007000200051 S0103-8478(07)03700251
                96d61b21-7218-4fbd-b5b5-91db1bdf3759

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 30 August 2006
                : 14 February 2006
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 23, Pages: 5
                Product

                SciELO Brazil

                Categories
                Patologia

                acantólise,horse,alopecia,crusts,acantholysis,cavalo,crostas
                acantólise, horse, alopecia, crusts, acantholysis, cavalo, crostas

                Comments

                Comment on this article