Health-related quality-of-life implications of cardiovascular events in individuals with type 2 diabetes mellitus: A subanalysis from the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)-TIMI 53 trial.

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Abstract

The impact of cardiovascular complications on health-related quality-of-life (HRQoL) in type 2 diabetes mellitus has not been clearly established. Using EQ5D utility data from SAVOR-TIMI 53, a large phase IV trial of saxagliptin versus placebo, we quantified the impact of cardiovascular and other major events on HRQoL.

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Journal

Journal ID (iso-abbrev): Diabetes Res. Clin. Pract.

Title: Diabetes research and clinical practice

Publisher: Elsevier BV

ISSN (Electronic): 1872-8227

ISSN (Print): 0168-8227

Publication date (Electronic): Aug 2017

Volume: 130

Affiliations

[1 ] Health Economics & Health Technology Assessment, Institute of Health & Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, United Kingdom. Electronic address: andrew.briggs@glasgow.ac.uk.

[2 ] TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

[3 ] Diabetes Unit, Hadassah Hebrew University Hospital, PO Box 12000, Jerusalem 91120, Israel.

[4 ] Broad Street Health Economics & Outcomes Research, 4016 Glen Dr, Vancouver V5V 4T3, Canada.

[5 ] AstraZeneca, 431 83 Molndal, Sweden.

[6 ] Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492, USA.

[7 ] MedImmune, One Medimmune Way, Gaithersburg, MD, 20878, USA.

Article

Publisher Item ID: S0168-8227(17)30067-0

DOI: 10.1016/j.diabres.2016.12.019

PubMed ID: 28554140

SO-VID: 97b741c4-06d9-44c4-a50e-597c82721b6d

History

Keywords: Diabetes mellitus,Cardiovascular,Health-related quality of life

Data availability:

Keywords: Diabetes mellitus, Cardiovascular, Health-related quality of life

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