BRCA1/BRCA2 germline mutations and chemotherapy-related hematological toxicity in breast cancer patients.

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Abstract

BRCA1 and BRCA2 proteins are central to DNA repair process through homologous recombination. We hypothesize that BRCA1/BRCA2 mutation carriers may exhibit increased hematological toxicity when receiving genotoxic chemotherapy.

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Journal

Journal ID (iso-abbrev): Breast Cancer Res. Treat.

Title: Breast cancer research and treatment

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1573-7217

ISSN (Print): 0167-6806

Publication date (Electronic): Apr 2019

Volume: 174

Issue: 3

Affiliations

[1 ] Department of Oncology, Hôpitaux Universitaires de Genève, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.

[2 ] Department of Genetic Medicine, Laboratory and Clinical Pathology, Hôpitaux Universitaires de Genève, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.

[3 ] Department of Medical Oncology, Centre Léon Bérard, 8 Rue Laennec, 69008, Lyon, France.

[4 ] Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69008, Lyon, France.

[5 ] Departement of Medical Oncology, Institut de Cancérologie des Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69310, Pierre-Bénite, France.

[6 ] UMR CNRS 5558, Université Lyon 1, Lyon, France.

[7 ] Division of Molecular Genetics, Hospices Civils de Lyon, Groupe Hospitalier Edouard Herriot, 5 Place d'Arsonval, 69003, Lyon, France.

[8 ] Unit of Prevention and Genetic Epidemiology, UMR CNRS 5558, Centre Léon Bérard, 8 Rue Laennec, 69008, Lyon, France.

[9 ] Department of Oncology, Hôpitaux Universitaires de Genève, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland. intidhar.labidi-galy@hcuge.ch.

[10 ] Department of Internal Medecine Specialities, Faculty of Medecine, Université de Genève, Rue Michel Servet 1, 1206, Geneva, Switzerland. intidhar.labidi-galy@hcuge.ch.

Article

Publisher Item ID: 10.1007/s10549-018-05127-2

DOI: 10.1007/s10549-018-05127-2

PubMed ID: 30635808

SO-VID: 98968b81-44f6-4750-846e-da8e75222a00

History

Keywords: Chemotherapy,Breast cancer,BRCA mutation,Febrile neutropenia,Toxicity,Haploinsufficiency

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Keywords: Chemotherapy, Breast cancer, BRCA mutation, Febrile neutropenia, Toxicity, Haploinsufficiency

BRCA1/BRCA2 germline mutations and chemotherapy-related hematological toxicity in breast cancer patients.

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Karger: Oncology

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