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      Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis

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          Abstract

          Obesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated the expression of 10 genes involved in lipid metabolism in Caenorhabditis elegans. Furthermore, leucosceptroid B was found to reduce fat storage, and downregulate the expression of two stearoyl-CoA desaturase (SCD) genes f at-6 and fat-7, and a fatty acid elongase gene elo-2 in wild-type C. elegans. In addition, leucosceptroid B significantly decreased fat accumulation in both fat-6 and fat-7 mutant worms but did not affect the fat storage of fat-6; fat-7 double mutant. These findings indicated that leucosceptroid B reduced fat storage depending on the downregulated expression of fat-6, fat-7 and elo-2 and thereby inhibiting the biosynthesis of the corresponding unsaturated fatty acid. These findings provide new insights into the development and utilization of plant sesterterpenoids as potential antilipemic agents.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier BV
          1875-5364
          20 December 2019
          : 17
          : 12
          : 892-899
          Affiliations
          1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
          2 Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
          3 University of Chinese Academy of Sciences, Beijing 100049, China
          Author notes
          *Corresponding author: LI Sheng-Hong, Tel: 86-871-65223035, E-mails: shli@ 123456mail.kib.ac.cn , LIU Yan, liuyan@ 123456mail.kib.ac.cn

          These authors have no conflict of interest to declare.

          Dedicated to Professor SUN Han-Dong on the Occasion of His 80th Birthday

          Article
          S1875-5364(19)30109-8
          10.1016/S1875-5364(19)30109-8
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Science Fund for Distinguished Young Scholars
          Award ID: 31525005
          Funded by: National Natural Science Foundation of China
          Award ID: 21937006
          Funded by: National Natural Science Foundation of China
          Award ID: 31770390
          Funded by: National Natural Science Foundation of China
          Award ID: 31800298
          Funded by: Yunnan Key Research and Development Program
          Award ID: 2019ZF011-2
          Funded by: Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products
          Award ID: 2018HC012
          Funded by: Science Foundation of Yunnan
          Award ID: 2018FA017
          Funded by: Youth Innovation Promotion Association and “Western Light” Program of CAS
          Award ID: awarded to LIU Yan
          This work was supported by the National Science Fund for Distinguished Young Scholars (No. 31525005), National Natural Science Foundation of China (Nos. 21937006, 31770390 and 31800298), Yunnan Key Research and Development Program (No. 2019ZF011-2), Yunnan Innovative Research Team for Discovery and Biosynthesis of Bioactive Natural Products (No. 2018HC012), Science Foundation of Yunnan (No. 2018FA017), and Youth Innovation Promotion Association and “Western Light” Program of CAS (awarded to LIU Yan).
          Categories
          Research article

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