Rapid Fatigue of Neuropeptide Secretion during Continual Electrical Stimulation

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Abstract

The vasopressin released by electrical stimulation of the isolated rat neurohypophysis into continuously perifused medium was measured by specific radioimmunoassay. The data revealed that the peak secretory rates achieved in the first few minutes of a period of 13-Hz stimulation are not maintained, but decline to a ‘plateau’ level, above the level of basal secretion, but markedly below the initial stimulated rate. After mathematical correction of the measured profile of peptide secretion to take account of the delayed appearance in the perifusate of hormone released from the interior of the gland it appears that peak secretory rates are not maintained beyond the first 2 min of stimulation: thereafter, stimulated secretion is stable at about 10% of the peak rate.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1982

Publication date (Print): 1982

Publication date (Electronic): 26 March 2008

Volume: 35

Issue: 6

Pages: 424-428

Affiliations

^aARC Institute of Animal Physiology, Babraham, Cambridge, and ^bARC Statistics Group, Department of Applied Biology, University of Cambridge, UK

Article

Publisher ID: 123418 Other ID: Neuroendocrinology 1982;35:424–428

DOI: 10.1159/000123418

PubMed ID: 7155300

SO-VID: 996b3bfc-f674-400d-8788-6b2e990ad326

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 14 April 1982

Date accepted : 08 June 1982

Page count

Pages: 5

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