Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

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Abstract

We explored which clinical and biochemical variables predict conversion from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) in a large international cohort.

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Journal

Journal ID (iso-abbrev): Mult. Scler.

Title: Multiple sclerosis (Houndmills, Basingstoke, England)

ISSN (Electronic): 1477-0970

ISSN (Print): 1352-4585

Publication date (Electronic): Jul 2015

Volume: 21

Issue: 8

Affiliations

[1 ] Blizard Institute, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, UK/ Departments of Neurology and Biomedicine, University Hospital Basel, University of Basel, Switzerland.

[2 ] Blizard Institute, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, UK.

[3 ] Wolfson Institute of Preventive Medicine, Queen Mary University of London, Barts and the London School for Medicine and Dentistry, UK.

[4 ] Department of Neurology and INSPE, Vita-Salute San Raffaele University, Scientific Institute San Raffaele, Italy.

[5 ] Department of Neurology, Erasmus MC University Medical Center, The Netherlands.

[6 ] Centre of Multiple Sclerosis, City Clinical Hospital#31, Russia.

[7 ] Institut de Génomique Fonctionelle, CNRS UMR5203, INSERM U661, Université Montpellier 1, Université Montpellier, France, and Hôpital Carémeau, France.

[8 ] Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari, Italy.

[9 ] Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.

[10 ] Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Institut de Receca Vall d'Hebron (VHIR), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Spain.

[11 ] Departments of Neurology and Clinical Chemistry, MS Center, Neurocampus Amsterdam, VU University Medical Centre Amsterdam, The Netherlands and BioMS-eu network.

[12 ] Department of Neurology, Innsbruck Medical University, Austria.

[13 ] Department of Radiology, Innsbruck Medical University, Austria.

[14 ] Department of Health Sciences and IRCAD, Eastern Piedmont University, Italy.

[15 ] Department of Neurology and Immunology, Hospital Ramón y Cajal, Spain.

[16 ] Department of Neurology, Charles University in Prague, Czech Republic.

[17 ] Department of Neurology, CSF Laboratory and MS Outpatient Unit, University of Ulm, Germany.

[18 ] Center for Neuroimmunology and Department of Neurology. Institut d'investigacions Biomèdiques August Pi Sunyer (IDIBAPS) - Hospital Clinic of Barcelona, Spain.

[19 ] Dr Orhan Öcalgiray Molecular Biology-Biotechnology and Genetics Research Centre, Istanbul Technical University, Turkey.

[20 ] Department of Neurology, Istanbul University, Turkey.

[21 ] Department of Neurology, Medical Faculty, Heinrich-Heine-University, Germany.

[22 ] Department of Neurology, University of Szeged, Hungary.

[23 ] C. Mondino National Neurological Institute, Italy.

[24 ] Pôle de Neurosciences Cliniques, Service de Neurologie, Centre de Résonance Magnétique Biologique et Médicale, Centre Hospitalier Universitaire Timone, Laboratoire d'histocompatibilité, Etablissement Français du Sang Alpes Méditerrannée, Aix Marseille Université, France.

[25 ] Department of Neurology, Medical University of Graz, Austria.

[26 ] Department of Neurology, Université de Lyon, Université Claude Bernard-Lyon 1, France.

[27 ] Clinic of Neurology, Belgrade University School of Medicine, Serbia.

[28 ] Unit of Functional Imaging, Glostrup Hospital, University of Copenhagen, Denmark.

[29 ] Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sweden.

[30 ] Neurology Unit, Dept. of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Policlinico.

[31 ] KG Jebsen Centre for MS-Research, Department of Clinical Medicine, Haukeland University Hospital, University of Bergen, Norway.

[32 ] Department of Neurology, University of Genoa, Italy.

[33 ] Centre for Experimental Neurological Therapies, S. Andrea Hospital-site, Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Faculty of Medicine and Psychology, Sapienza University, Italy.

[34 ] Department of Neurology of Hospital Británico of Buenos Aires, Argentina.

[35 ] Department of Neurology, Medical University of Lublin, Poland.

[36 ] Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.

[37 ] Department of Neurology, University of Toulouse, France.

[38 ] MS Unit, Neurology Department, La Fe University and Polytechnic Hospital, Instituto de investigación Sanitaria La Fe, Spain.

[39 ] Departments of Neurology and Biomedicine, University Hospital Basel, University of Basel, Switzerland.

[40 ] MS Centre, SCDU Neurology, Head and Neck Department, AOU Maggiore della Carità, Italy.

[41 ] Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, UK.

[42 ] Blizard Institute, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, UK g.giovannoni@qmul.ac.uk.

Article

Publisher Item ID: 1352458514568827

DOI: 10.1177/1352458514568827

PubMed ID: 25680984

SO-VID: 99fd858b-7084-4413-8de1-3b2eb7516d9f

History

Keywords: Clinically definite multiple sclerosis (CDMS),Epstein-Barr nuclear antigen 1 (EBNA-1),clinically isolated syndrome (CIS),oligoclonal bands (OCBs),serum 25-hydroxyvitamin D3 (25-OH-D)

Data availability:

Keywords: Clinically definite multiple sclerosis (CDMS), Epstein-Barr nuclear antigen 1 (EBNA-1), clinically isolated syndrome (CIS), oligoclonal bands (OCBs), serum 25-hydroxyvitamin D3 (25-OH-D)

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

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