White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts.

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Abstract

Sickle cell anemia is associated with compromised oxygen-carrying capability of hemoglobin and a high incidence of overt and silent stroke. However, in children with no evidence of cerebral infarction, there are changes in brain morphometry relative to healthy controls, which may be related to chronic anemia and oxygen desaturation.

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Author and article information

Journal

Journal ID (iso-abbrev): Stroke

Title: Stroke

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4628

ISSN (Print): 0039-2499

Publication date (Electronic): Jul 2015

Volume: 46

Issue: 7

Affiliations

[1 ] From the Developmental Imaging and Biophysics Section (J.M.K., J.D.C., C.A.C.), Clinical Neurosciences Section (F.J.K.), and Cognitive Neuroscience and Neuropsychiatry Section (E.L.S., R.E.), UCL Institute of Child Health, London, United Kingdom; Department of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom (M.J.H.); Department of Paediatric Haematology, Barts and The London Hospital NHS Trust, London, United Kingdom (P.T.); Department of Paediatrics, Whittington Hospital NHS Trust, London, United Kingdom (A.R.); Department of Paediatrics, North Middlesex University Hospital NHS Trust, London, United Kingdom (O.W.); Wessex Neurological Centre (S.B.), and Department of Child Health (F.J.K.), Southampton University Hospitals NHS Trust, Southampton, United Kingdom (S.B.); and Department of Radiology, Great Ormond Street Hospital, London, United Kingdom (T.C.S.C.).

[2 ] From the Developmental Imaging and Biophysics Section (J.M.K., J.D.C., C.A.C.), Clinical Neurosciences Section (F.J.K.), and Cognitive Neuroscience and Neuropsychiatry Section (E.L.S., R.E.), UCL Institute of Child Health, London, United Kingdom; Department of Clinical Neuroscience, University of Cambridge, Cambridge, United Kingdom (M.J.H.); Department of Paediatric Haematology, Barts and The London Hospital NHS Trust, London, United Kingdom (P.T.); Department of Paediatrics, Whittington Hospital NHS Trust, London, United Kingdom (A.R.); Department of Paediatrics, North Middlesex University Hospital NHS Trust, London, United Kingdom (O.W.); Wessex Neurological Centre (S.B.), and Department of Child Health (F.J.K.), Southampton University Hospitals NHS Trust, Southampton, United Kingdom (S.B.); and Department of Radiology, Great Ormond Street Hospital, London, United Kingdom (T.C.S.C.). fenella.kirkham@ucl.ac.uk.

Article

Publisher Item ID: STROKEAHA.115.008721

DOI: 10.1161/STROKEAHA.115.008721

PubMed ID: 25967572

SO-VID: 99fe8e16-4d8d-42f2-be5f-c25af0c90d3f

History

Keywords: diffusion,pediatrics,sickle cell anemia

Data availability:

Keywords: diffusion, pediatrics, sickle cell anemia

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