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Abstract
The infection-and-treatment method (ITM) for immunization of cattle against East Coast
fever has historically been used only on a limited scale because of logistical and
policy constraints. Recent large-scale deployment among pastoralists in Tanzania has
stimulated demand. Concurrently, a suite of molecular tools, developed from the Theileria
parva genome, has enabled improved quality control of the immunizing stabilate and
post-immunization monitoring of the efficacy and biological impact of ITM in the field.
This article outlines the current status of ITM immunization in the field, with associated
developments in the molecular epidemiology of T. parva.