The iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology

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Abstract

The iBerry study is a population-based cohort study designed to investigate the transition from subclinical symptoms to a psychiatric disorder. Adolescents were selected based on their self-reported emotional and/or behavioral problems assessed by completing the strengths and difficulties questionnaire-youth (SDQ-Y) in their first year of high school. A total of 16,736 SDQ-Y questionnaires completed in the academic years 2014–2015 and 2015–2016 by students in the greater Rotterdam area in the Netherlands were screened. A high-risk group of adolescents was then selected based on the 15% highest-scoring adolescents, and a low-risk group was randomly selected from the 85% lowest-scoring adolescents, with a 2.5:1 ratio between the number of high-risk and low-risk adolescents. These adolescents were invited to come with one parent for a baseline visit consisting of interviews, questionnaires, neuropsychological tests, and biological measurements to assess determinants of psychopathology. A total of 1022 high-risk and low-risk adolescents (mean age at the first visit: 15.0 years) enrolled in the study. The goal of the iBerry study is to follow these adolescents for a 10-year period in order to monitor any changes in their symptoms. Here, we present the study design, response rate, inclusion criteria, and the characteristics of the cohort; in addition, we discuss possible selection effects. We report that the oversampling procedure was successful at selecting a cohort of adolescents with a high rate of psychiatric problems based on comprehensive multi-informant measurements. The future results obtained from the iBerry Study will provide new insights into the way in which the mental health of high-risk adolescents changes as they transition to adulthood. These findings will therefore facilitate the development of strategies designed to optimize mental healthcare and prevent psychopathology.

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The online version contains supplementary material available at 10.1007/s10654-021-00740-w.

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Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Theo Vos, Ryan M Barber, Brad E. Bell … (2015)

Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.

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Psychometric properties of the strengths and difficulties questionnaire.

ROBERT GOODMAN (2001)

To describe the psychometric properties of the Strengths and Difficulties Questionnaire (SDQ), a brief measure of the prosocial behavior and psychopathology of 3-16-year-olds that can be completed by parents, teachers, or youths. A nationwide epidemiological sample of 10,438 British 5-15-year-olds obtained SDQs from 96% of parents, 70% of teachers, and 91% of 11-15-year-olds. Blind to the SDQ findings, all subjects were also assigned DSM-IVdiagnoses based on a clinical review of detailed interview measures. The predicted five-factor structure (emotional, conduct, hyperactivity-inattention, peer, prosocial) was confirmed. Internalizing and externalizing scales were relatively "uncontaminated" by one another. Reliability was generally satisfactory, whether judged by internal consistency (mean Cronbach a: .73), cross-informant correlation (mean: 0.34), or retest stability after 4 to 6 months (mean: 0.62). SDQ scores above the 90th percentile predicted a substantially raised probability of independently diagnosed psychiatric disorders (mean odds ratio: 15.7 for parent scales, 15.2 for teacher scales, 6.2 for youth scales). The reliability and validity of the SDQ make it a useful brief measure of the adjustment and psychopathology of children and adolescents.

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Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

Andy Boyd, Jean Golding, John Macleod … (2012)

The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enrol pregnant women in the Bristol area of the UK during 1990–92; this was extended to include additional children eligible using the original enrolment definition up to the age of 18 years. The children from 14 541 pregnancies were recruited in 1990–92, increasing to 15 247 pregnancies by the age of 18 years. This cohort profile describes the index children of these pregnancies. Follow-up includes 59 questionnaires (4 weeks–18 years of age) and 9 clinical assessment visits (7–17 years of age). The resource comprises a wide range of phenotypic and environmental measures in addition to biological samples, genetic (DNA on 11 343 children, genome-wide data on 8365 children, complete genome sequencing on 2000 children) and epigenetic (methylation sampling on 1000 children) information and linkage to health and administrative records. Data access is described in this article and is currently set up as a supported access resource. To date, over 700 peer-reviewed articles have been published using ALSPAC data.

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Contributors

Nina H. Grootendorst-van Mil: n.grootendorst@erasmusmc.nl

Journal

Journal ID (nlm-ta): Eur J Epidemiol

Journal ID (iso-abbrev): Eur J Epidemiol

Title: European Journal of Epidemiology

Publisher: Springer Netherlands (Dordrecht )

ISSN (Print): 0393-2990

ISSN (Electronic): 1573-7284

Publication date (Electronic): 1 April 2021

Publication date PMC-release: 1 April 2021

Publication date (Print): 2021

Volume: 36

Issue: 4

Pages: 453-464

Affiliations

[1 ]GRID grid.5645.2, ISNI 000000040459992X, Department of Psychiatry, , Erasmus MC University Medical Center, ; Rotterdam, The Netherlands

[2 ]GRID grid.5645.2, ISNI 000000040459992X, Epidemiological and Social Psychiatric Research Institute (ESPRi), Department of Psychiatry, , Erasmus MC University Medical Center, ; Rotterdam, The Netherlands

[3 ]GRID grid.5645.2, ISNI 000000040459992X, Department of Epidemiology, , Erasmus MC University Medical Center, ; Rotterdam, The Netherlands

[4 ]GRID grid.5645.2, ISNI 000000040459992X, Department of Child and Adolescent Psychiatry and Psychology, , Erasmus MC, University Medical Center, ; Rotterdam, The Netherlands

[5 ]GRID grid.38142.3c, ISNI 000000041936754X, Department of Social and Behavioral Sciences, , Harvard T.H. Chan School of Public Health, ; Boston, USA

Article

Publisher ID: 740

DOI: 10.1007/s10654-021-00740-w

PMC ID: 8076148

PubMed ID: 33796978

SO-VID: 9ba81925-0821-414d-860e-f023ad2e980a

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 1 September 2020

Date accepted : 13 March 2021

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ScienceOpen disciplines: Public health

Keywords: epidemiology,psychopathology,cohort study,design,adolescents,high-risk

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ScienceOpen disciplines: Public health

Keywords: epidemiology, psychopathology, cohort study, design, adolescents, high-risk

The iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology

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Chinese Journal of School Health

Most cited references 42

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

Psychometric properties of the strengths and difficulties questionnaire.

Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children

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