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      Current Trends of Big Data Research Using the Korean National Health Information Database

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          Abstract

          Recently, medical research using big data has become very popular, and its value has become increasingly recognized. The Korean National Health Information Database (NHID) is representative of big data that combines information obtained from the National Health Insurance Service collected for claims and reimbursement of health care services and results obtained from general health examinations provided to all Korean adults. This database has several strengths and limitations. Given the large size, various laboratory data, and questionnaires obtained from medical check-ups, their longitudinal nature, and long-term accumulation of data since 2002, carefully designed studies may provide valuable information that is difficult to obtain from other forms of research. However, consideration of possible bias and careful interpretation when defining causal relationships is also important because the data were not collected for research purposes. After the NHID became publicly available, research and publications based on this database have increased explosively, especially in the field of diabetes and metabolism. This article reviews the history, structure, and characteristics of the Korean NHID. Recent trends in big data research using this database, commonly used operational diagnosis, and representative studies have been introduced. We expect further progress and expansion of big data research using the Korean NHID.

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          Cohort Profile: The National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea.

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            Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service

            In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.
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              Cardiovascular Research Using the Korean National Health Information Database

              The Korean National Health Information Database (NHID) contains nationwide claims data, including sociodemographic data, health care utilization, health screening data, and healthcare provider information. To compensate for the limitations of randomized clinical trials, real-world observational studies using claims data have emerged as a novel research tool. We summarized the structure of the Korean NHID and the recent researches conducted in the field of cardiovascular science. Epidemiological studies, prescription patterns, temporal trends, comparison of effectiveness and safety of treatments, variability index using laboratory data, and rare intractable disease constitute interesting topics of research in cardiovascular science using the NHID. The operational definition of covariates and clinical outcomes is important for researchers interested in using the NHID data as new tools to prove their hypothesis. A step-by-step approach adopted by a team of data scientists, epidemiologists, statisticians, and clinical researchers may be most effective while designing research studies. The ultimate direction of research using the NHID should aim to improve the welfare of the public by promoting public health, reducing medical costs, and guiding healthcare policies.
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                Author and article information

                Journal
                Diabetes Metab J
                Diabetes Metab J
                Diabetes & Metabolism Journal
                Korean Diabetes Association
                2233-6079
                2233-6087
                July 2022
                27 July 2022
                : 46
                : 4
                : 552-563
                Affiliations
                [1 ]Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
                [2 ]Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea
                [3 ]Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
                [4 ]Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul, Korea
                Author notes
                Corresponding author: Seung-Hwan Lee https://orcid.org/0000-0002-3964-3877 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea E-mail: hwanx2@ 123456catholic.ac.kr
                Author information
                https://orcid.org/0000-0003-3205-9114
                https://orcid.org/0000-0002-3964-3877
                Article
                dmj-2022-0193
                10.4093/dmj.2022.0193
                9353560
                35929173
                9bad77f0-944a-4f2b-9caa-bb60d270b39e
                Copyright © 2022 Korean Diabetes Association

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 6 June 2022
                : 30 June 2022
                Categories
                Review
                Others

                Endocrinology & Diabetes
                database,diabetes mellitus,korea,metabolism,national health programs
                Endocrinology & Diabetes
                database, diabetes mellitus, korea, metabolism, national health programs

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