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      Function, life histories, and biographies of Lower Paleolithic patinated flint tools from Late Acheulian Revadim, Israel

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          Abstract

          Flint tools exhibiting modified patinated surfaces (“double patina”, or post-patination flaked items) provide a glimpse into Paleolithic lithic recycling, stone economy, and human choices. Different life cycles of such items are visually evident by the presence of fresh new modified surfaces alongside old patinated ones (according to color and texture differences). New modifications testify to a gap in time between the previous life cycle of the patinated flaked item and its new one. The aim of the current study is to reconstruct the functional properties and life cycles of a sample of modified patinated flaked tools from Late Acheulian Revadim, Israel by applying use-wear and residue analyses. The results of the functional study allow a better understanding of the practical reasoning behind the collection and recycling of old flint tools, while additional inputs from theoretical and methodological advancements assist in reconstructing their probable role in the worldviews of the site’s inhabitants.

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          Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease

          Krabbe disease (KD) is a neurodegenerative disorder caused by the lack of β- galactosylceramidase enzymatic activity and by widespread accumulation of the cytotoxic galactosyl-sphingosine in neuronal, myelinating and endothelial cells. Despite the wide use of Twitcher mice as experimental model for KD, the ultrastructure of this model is partial and mainly addressing peripheral nerves. More details are requested to elucidate the basis of the motor defects, which are the first to appear during KD onset. Here we use transmission electron microscopy (TEM) to focus on the alterations produced by KD in the lower motor system at postnatal day 15 (P15), a nearly asymptomatic stage, and in the juvenile P30 mouse. We find mild effects on motorneuron soma, severe ones on sciatic nerves and very severe effects on nerve terminals and neuromuscular junctions at P30, with peripheral damage being already detectable at P15. Finally, we find that the gastrocnemius muscle undergoes atrophy and structural changes that are independent of denervation at P15. Our data further characterize the ultrastructural analysis of the KD mouse model, and support recent theories of a dying-back mechanism for neuronal degeneration, which is independent of demyelination.
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            Ian Hodder (2012)
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              Cosmological Deixis and Amerindian Perspectivism

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                Author and article information

                Contributors
                barefrati@mail.tau.ac.il
                flavia.venditti@uni-tuebingen.de
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                3 March 2022
                3 March 2022
                2022
                : 12
                : 2885
                Affiliations
                [1 ]GRID grid.12136.37, ISNI 0000 0004 1937 0546, Department of Archaeology and Ancient Near East Cultures, , Tel Aviv University, ; POB 39040, 66978 Tel Aviv, Israel
                [2 ]Scientific Methodologies Applied To Cultural Heritage (SMATCH), Rome, Italy
                [3 ]GRID grid.10392.39, ISNI 0000 0001 2190 1447, Department of Early Prehistory and Quaternary Ecology, , University of Tübingen, ; Schloß Hohentübingen, Burgsteige 11, 72070 Tübingen, Germany
                [4 ]GRID grid.7841.a, LTFAPA Laboratory, Department of Classics, , Sapienza University of Rome, ; P.Le Aldo Moro, 00185 Rome, Italy
                Article
                6823
                10.1038/s41598-022-06823-2
                8894402
                35241694
                9c6077ee-fb9d-423e-9d76-786a67d8d253
                © The Author(s) 2022

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 10 November 2021
                : 7 February 2022
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100006601, Ministero degli Affari Esteri e della Cooperazione Internazionale;
                Funded by: FundRef http://dx.doi.org/10.13039/501100004271, Sapienza Università di Roma;
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                archaeology
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                archaeology

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