Loss of the hyaluronan receptor RHAMM prevents constrictive artery wall remodeling.

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Abstract

Constrictive extracellular matrix (ECM) remodeling contributes significantly to restenosis after arterial reconstruction, but its molecular regulation is poorly defined. Hyaluronan (HA) accumulates within ECM at sites of injury where it is thought to facilitate smooth muscle cell (SMC) trafficking and collagen remodeling analogous to its role in cutaneous wound healing. SMC receptors for HA include receptor for hyaluronan-mediated motility (RHAMM), which mediates HA-induced migration. We hypothesized RHAMM would also mediate SMC-matrix interactions to alter the extent of constrictive remodeling.

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Journal

Journal ID (iso-abbrev): J. Vasc. Surg.

Title: Journal of vascular surgery

ISSN (Electronic): 1097-6809

ISSN (Print): 0741-5214

Publication date (Electronic): Mar 2014

Volume: 59

Issue: 3

Affiliations

[1 ] Department of Vascular and Endovascular Surgery, Wake Forest University Health Sciences, Winston-Salem, NC.

[2 ] Department of Vascular and Endovascular Surgery, Wake Forest University Health Sciences, Winston-Salem, NC. Electronic address: rgeary@wakehealth.edu.

Article

Publisher Item ID: S0741-5214(13)00775-1 Mid ID: NIHMS494158

DOI: 10.1016/j.jvs.2013.03.047

PMC ID: 3844090

PubMed ID: 23768790

SO-VID: 9cc5a5d8-68ed-479b-8815-5095e60b7e29

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