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      Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

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          Abstract

          <p class="first" id="d6858668e218">Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19. </p>

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          Author and article information

          Journal
          Nature Medicine
          Nat Med
          Springer Science and Business Media LLC
          1078-8956
          1546-170X
          May 12 2020
          Article
          10.1038/s41591-020-0901-9
          32398875
          9d32cf1e-5d0d-4b41-b77f-705cc334ad55
          © 2020

          Free to read

          http://www.springer.com/tdm

          http://www.springer.com/tdm

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