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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Mingfeng Liao ,
Yang Liu ,
Jing Yuan ,
Yanling Wen ,
Gang Xu ,
Juanjuan Zhao ,
Lin Cheng ,
Jinxiu Li ,
Xin Wang ,
Fuxiang Wang ,
Lei Liu ,
Ido Amit ,
Shuye Zhang ,
Zheng Zhang
May 12 2020
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Abstract
<p class="first" id="d6858668e218">Respiratory immune characteristics associated with
Coronavirus Disease 2019 (COVID-19)
severity are currently unclear. We characterized bronchoalveolar lavage fluid immune
cells from patients with varying severity of COVID-19 and from healthy people by using
single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant
in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases
were characterized by the presence of highly clonally expanded CD8+ T cells. This
atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms
underlying pathogenesis and recovery in COVID-19.
</p>