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      Ventriculitis: a rare case of primary cerebral toxoplasmosis in AIDS patient and literature review

      case-report

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          Abstract

          Cerebral toxoplasmosis remains the most important neurological opportunistic infection and the most common cause of intracerebral mass lesion in patients with acquired immunodeficiency syndrome (AIDS). We report a case of an adult AIDS patient with an atypical pattern of toxoplasma encephalitis, presenting with ventriculitis and obstructive hydrocephalus without any focal parenchymal lesion.

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          Most cited references18

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          Influence of viral hepatitis on HIV infection.

          Jürgen K Rockstroh (2005)
          The natural history of HBV is known to be complicated by HIV-co-infection. In contrast, the effect of HBV on the outcome of patients infected with HIV-1 is controversial. Some cohort studies from the pre-HAART era described a more rapid progression to AIDS in patients carrying antibodies to the core-antigen or having chronic HBV infection, but post-HAART studies did not detect any impact of HBV co-infection on HIV-disease progression. Similarly, studies assessing the impact of HCV on progression of HIV-disease delivered conflicting results. In the Swiss cohort study, the presence of HCV was independently associated with an increased risk of progression to AIDS and death. Subsequent studies, however, did not find any difference in survival. Most interestingly, the EuroSIDA cohort analysis found no difference between HCV-positive and HCV-negative HIV-patients starting HAART in the time needed to decrease viral loads to less than 400 copies as well as in the time needed to increase CD4-counts by 50%. In summary, there are no major differences in HIV-related mortality between hepatitis B or C co-infected individuals and patients infected with HIV alone, particularly if antiretroviral treatment is given. There is, however, an increased risk of liver disease related morbidity and mortality as well as more hepatoxicity under antiretroviral treatment regimens.
          Article 0 comments Cited 51 times – based on 0 reviews     Review now
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            Ventriculitis and hydrocephalus: an unusual presentation of toxoplasmosis in an adult with human immunodeficiency virus

            T. de Silva, M. Raychaudhuri, M Poulton … (2005)
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              Prevalence, associated factors, and prognostic determinants of AIDS-related toxoplasmic encephalitis in the era of advanced highly active antiretroviral therapy

              A Antinori, D. Larussa, A Cingolani … (2004)
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                Author and article information

                Contributors
                Gláucia Fernandes Cota: Role: ND
                Elisa Caroline Pereira Assad: Role: ND
                Paulo Pereira Christo: Role: ND
                Alexandre Varella Giannetti: Role: ND
                José Augusto Malheiros dos Santos Filho: Role: ND
                Marcelo Antonio Pascoal Xavier: Role: ND
                Journal
                Journal ID (publisher): bjid
                Title: Brazilian Journal of Infectious Diseases
                Abbreviated Title: Braz J Infect Dis
                Publisher: Brazilian Society of Infectious Diseases (Salvador )
                ISSN: 1678-4391
                Publication date (Print): February 2008
                Volume: 12
                Issue: 1
                Pages: 101-104
                Affiliations
                [1 ] Eduardo de Menezes Hospital
                [2 ] Universidade Federal de Minas Gerais Brazil
                [3 ] Universidade Federal de Minas Gerais Brazil
                Article
                Publisher ID: S1413-86702008000100022
                DOI: 10.1590/S1413-86702008000100022
                SO-VID: 9dc8a6a2-a8ec-43d7-8204-43d11751ea2e
                License:

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1413-8670&lng=en
                Categories
                Subject: INFECTIOUS DISEASES

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: Cerebral toxoplasmosis,ventriculitis,hydrocephalus,AIDS
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: Cerebral toxoplasmosis, ventriculitis, hydrocephalus, AIDS

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