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      Comparison of the Morphological and Physical Properties of Different Absorbent Wound Dressings

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          Abstract

          Good quality wound dressings should have exceptional properties for usage, such as being able to remove excess wound exudates, having rapid dehydration, and providing optimal water vapour permeability. This study evaluated and compared the morphological and physical properties of six different commercially absorbent wound dressings in Thailand: two hydrocolloids, two alginates, and two foams. These wound dressings are available in a variety of components and structures, some of which have a multilayer structure. The results showed that the calcium sodium alginate dressings had better absorption properties than the calcium alginate dressings, hydrocolloid dressings, hydrocolloid with foam layer dressings, foam with polyurethane film layer dressings, and foam with hydrogel and polyurethane film layer dressings. Furthermore, the calcium sodium alginate dressings had the highest rate of dehydration and provided an optimal water vapour transmission rate. However, the calcium sodium alginate dressings could not retain the original structure after being submerged with a wound exudate.

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          Wound dressings.

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            Preparation, characteristics and assessment of a novel gelatin-chitosan sponge scaffold as skin tissue engineering material.

            In order to develop a skin tissue engineering material for wound dressing application, a novel gelatin-chitosan sponge scaffold was designed and studied. The effect of chitosan and gelatin ratio on the morphology, pore size, porosity, water uptake capacity, water retention capacity and the degradation behavior were evaluated. Biocompatibility was investigated by both MTT method and AO/EB staining method. Antibacterial assessment and in vivo pharmacodynamic was also studied to evaluate the potential for wound healing. Results showed the sponge scaffold have uniform porous structure with pore size range between 120 and 140 μm, high porosity (>90%), high water uptake capacity (>1500%), high water retention capacity (>400%), and degradation percent in 28 days between 38.3 and 53.9%. Biocompatibility results showed that the activity of cells could not be affected by the nature of the sponge and it was suitable for cell adhesion and proliferation for 21 days. In vivo evaluation indicated that the sponge scaffold could offer effective support and attachment to cells for skin wound healing. In conclusion, the developed sponge scaffold was a potential skin tissue engineering material with appropriate physical properties and good biocompatibility.
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              Choosing a wound dressing, part 1

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                Author and article information

                Contributors
                Journal
                Dermatol Res Pract
                Dermatol Res Pract
                DRP
                Dermatology Research and Practice
                Hindawi
                1687-6105
                1687-6113
                2018
                21 May 2018
                : 2018
                : 9367034
                Affiliations
                Department of Pharmacy Practice, Faculty of Pharmacy, Rangsit University, Pathum Thani, Thailand
                Author notes

                Academic Editor: Markus Stucker

                Author information
                http://orcid.org/0000-0002-2773-0105
                Article
                10.1155/2018/9367034
                5987330
                29951092
                9f26e54d-10d3-4df3-ab7f-03f42b48fc3c
                Copyright © 2018 Sukhontha Hasatsri et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 November 2017
                : 14 March 2018
                : 3 April 2018
                Funding
                Funded by: Rangsit University
                Categories
                Research Article

                Dermatology
                Dermatology

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