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      Epinephrine, compared with arginine vasopressin, is associated with similar haemodynamic effects but significantly improved brain oxygenation in the early phase of anaphylactic shock in rats: An experimental study.

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          Abstract

          In contrast to other types of shock, anaphylactic shock decreases cerebral blood flow more than would be expected from severe arterial hypotension, thus potentially affecting survival through brain ischaemia/hypoxia. We hypothesised that epinephrine (EPI) used as a first-line treatment of anaphylactic shock and arginine vasopressin (AVP) proposed in case of EPI refractoriness may have different effects on brain oxygenation.

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          Author and article information

          Journal
          Eur J Anaesthesiol
          European journal of anaesthesiology
          Ovid Technologies (Wolters Kluwer Health)
          1365-2346
          0265-0215
          Aug 2015
          : 32
          : 8
          Affiliations
          [1 ] From the Groupe Choc, Contrat AVENIR INSERM U1116, Faculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy, France (FZ, GB, BL, GA, J-MM, P-MM), Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China (FZ), Pôle Anesthésie, Réanimations Chirurgicales, SAMU, Hôpitaux Universitaires de Strasbourg, and Laboratoire EA 3072: « Mitochondries, stress oxydant et protection musculaire », Institut de Physiologie, Faculté de Médecine, Université de Strasbourg, Strasbourg (FZ, OC, WO, P-MM), Pôle Urgences Réanimation Anesthésie Douleur, Hôpital Maison Blanche, CHU de Reims, Reims (JD, J-MM), Département d'Anesthésie-Réanimation Chirurgicale, Centre Hospitalier Universitaire (CHU) Central, Nancy (GB, GA), Laboratoire U961, Faculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy (SNT), Département d'Anesthésie-Réanimation Chirurgicale, Hôpital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris, and Unité INSERM U1148, Laboratory for Vascular Translational Science (LVTS), Université Paris Diderot, Sorbonne Paris Cité, Paris (DL), Service de Réanimation Médicale Brabois, CHU de Nancy, Vandœuvre-lès-Nancy, France (BL).
          Article
          00003643-201508000-00008
          10.1097/EJA.0000000000000238
          26244468

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