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      Safety, immunogenicity and infectivity of new live attenuated influenza vaccines.

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          Abstract

          Live attenuated influenza vaccines (LAIVs) are believed to be immunologically superior to inactivated influenza vaccines, because they can induce a variety of adaptive immune responses, including serum antibodies, mucosal and cell-mediated immunity. In addition to the licensed cold-adapted LAIV backbones, a number of alternative LAIV approaches are currently being developed and evaluated in preclinical and clinical studies. This review summarizes recent progress in the development and evaluation of LAIVs, with special attention to their safety, immunogenicity and infectivity for humans, and discusses their perspectives for the future.

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          Author and article information

          Journal
          Expert Rev Vaccines
          Expert review of vaccines
          Informa UK Limited
          1744-8395
          1476-0584
          2015
          : 14
          : 10
          Affiliations
          [1 ] a Department of Virology, Institute of Experimental Medicine, 12 Acad. Pavlov Street, Saint Petersburg, Russia.
          Article
          10.1586/14760584.2015.1075883
          26289975

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