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      A case report of paroxysmal atrial fibrillation in three pulmonary veins presenting a common trunk

      case-report

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          Abstract

          Background

          The pulmonary vein (PV) variant is present in 23–38% of patients who undergo atrial fibrillation ablation, and the common inferior PV (CIPV) variant is a rare PV variant that has been reported in 0.9–1.5% of patients. The arrhythmogenicity of the common trunk of the CIPV is unknown.

          Case summary

          A 77-year-old woman underwent catheter ablation for paroxysmal atrial fibrillation (AF). Preoperative computed tomography revealed a common trunk from which the bilateral inferior PVs and a left superior PV originated. The voltage map of the left atrium (LA) showed three PVs stemming from a common trunk. There was a low-voltage area bounded by the common trunk entrance. An isolation line was created to connect the right superior PV and the common trunk. Twelve months later, AF recurred. The voltage map in second session showed residual irregular potentials at the boundary between the common trunk and the LA, and posterior wall isolation was performed. Postoperatively, the patient maintained sinus rhythm with no antiarrhythmic drugs during the 12-month follow-up period.

          Discussion

          The CIPV is likely to predict the AF recurrence, even if preoperative voltage mapping shows a low voltage area. Substrate modification should be performed on abnormal potentials at the entrance of the common trunk, even though no potential is detected in the PVs or their antrum.

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          Most cited references13

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          Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.

          Atrial fibrillation, the most common sustained cardiac arrhythmia and a major cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has not been studied. We studied 45 patients with frequent episodes of atrial fibrillation (mean [+/-SD] duration, 344+/-326 minutes per 24 hours) refractory to drug therapy. The spontaneous initiation of atrial fibrillation was mapped with the use of multielectrode catheters designed to record the earliest electrical activity preceding the onset of atrial fibrillation and associated atrial ectopic beats. The accuracy of the mapping was confirmed by the abrupt disappearance of triggering atrial ectopic beats after ablation with local radio-frequency energy. A single point of origin of atrial ectopic beats was identified in 29 patients, two points of origin were identified in 9 patients, and three or four points of origin were identified in 7 patients, for a total of 69 ectopic foci. Three foci were in the right atrium, 1 in the posterior left atrium, and 65 (94 percent) in the pulmonary veins (31 in the left superior, 17 in the right superior, 11 in the left inferior, and 6 in the right inferior pulmonary vein). The earliest activation was found to have occurred 2 to 4 cm inside the veins, marked by a local depolarization preceding the atrial ectopic beats on the surface electrocardiogram by 106+/-24 msec. Atrial fibrillation was initiated by a sudden burst of rapid depolarizations (340 per minute). A local depolarization could also be recognized during sinus rhythm and abolished by radiofrequency ablation. During a follow-up period of 8+/-6 months after ablation, 28 patients (62 percent) had no recurrence of atrial fibrillation. The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation. These foci respond to treatment with radio-frequency ablation.
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            Pre-existent left atrial scarring in patients undergoing pulmonary vein antrum isolation: an independent predictor of procedural failure.

            The goal of this study was to assess the impact of left atrial scarring (LAS) on the outcome of patients undergoing pulmonary vein antrum isolation (PVAI) for atrial fibrillation (AF). Left atrial scarring may be responsible for both the perpetuation and genesis of AF. A total of 700 consecutive patients undergoing first-time PVAI were studied. Before ablation, extensive voltage mapping of the left atrium (LA) was performed using a multipolar Lasso catheter guided by intracardiac echocardiography (ICE). Patients with LAS were defined by a complete absence of electrographic recording by a circular mapping catheter in multiple LA locations, and this was validated by electroanatomic mapping. All four pulmonary vein antra and the superior vena cava were isolated using an ICE-guided technique. Patients were followed at least nine months for late AF recurrence. Univariate and multivariate analyses were performed to assess the predictive value of LAS and other variables on outcome. Of 700 patients, 42 had LAS, which represented 21 +/- 11% of the LA surface area by electroanatomic mapping. Patients with LAS had a significantly higher AF recurrence (57%) compared with non-LAS patients (19%, p = 0.003). Also, LAS was associated with a significantly larger LA size, lower ejection fraction, and higher C-reactive protein levels. Univariate analysis revealed age, nonparoxysmal AF, and LAS as predictors of recurrence. Multivariate analysis showed LAS as the only independent predictor of recurrence (hazard ratio 3.4, 95% confidence interval 1.3 to 9.4; p = 0.01). Pre-existent LAS in patients undergoing PVAI for AF is a powerful, independent predictor of procedural failure. Left atrial scarring is associated with a lower EF, larger LA size, and increased inflammatory markers.
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              Non-Pulmonary Vein Triggers of Atrial Fibrillation Are Likely to Arise from Low-Voltage Areas in the Left Atrium

              The pathophysiology of non-pulmonary vein (PV) triggers of atrial fibrillation (AF) is unclear. We hypothesized that left atrial non-PV (LANPV) triggers are associated with atrial tissue degeneration. This study analyzed 431 patients that underwent catheter ablation (mean age 62 yrs, 303 men, 255 paroxysmal AF [pAF] patients). Clinical and electrophysiological characteristics of non-PV trigger were analyzed. Fifty non-PV triggers in 40 patients (9.3%) were documented; LANPV triggers were the most prevalent (n = 19, 38%). LANPV triggers were correlated with non-paroxysmal AF (non-pAF) (OR 3.31, p = 0.04) whereas right atrial non-PV (RANPV) triggers (n = 14) and SVC triggers (n = 17) were not. The voltage at the LANPV sites during SR was 0.3 ± 0.16 mV (p < 0.001 vs. control site). Low-voltage areas (LVAs) in the LA were significantly greater in non-pAF compared to pAF (14.2% vs. 5.8%, p < 0.01). RANPV trigger sites had preserved voltage (0.74 ± 0.48 mV). Long-term outcomes of patients with non-PV triggers treated with tailored targeting strategies were not significantly inferior to those without non-PV triggers. In conclusion, non-PV triggers arise from the LA with degeneration, which may have an important role in AF persistence. A trigger-oriented, patient-tailored ablation strategy considering LA voltage map may be feasible and effective in persistent/recurrent AF.
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                Author and article information

                Contributors
                Role: Handling Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Role: Editor
                Journal
                Eur Heart J Case Rep
                Eur Heart J Case Rep
                ehjcr
                European Heart Journal: Case Reports
                Oxford University Press (US )
                2514-2119
                January 2023
                17 December 2022
                17 December 2022
                : 7
                : 1
                : ytac481
                Affiliations
                Department of Cardiology, Tokyo Metropolitan Hiroo Hospital , 2-34-10, Ebisu, Shibuya-ku, Tokyo 150-0013, Japan
                Department of Cardiology, Tokyo Metropolitan Hiroo Hospital , 2-34-10, Ebisu, Shibuya-ku, Tokyo 150-0013, Japan
                Department of Cardiology, Tokyo Metropolitan Hiroo Hospital , 2-34-10, Ebisu, Shibuya-ku, Tokyo 150-0013, Japan
                Department of Cardiology, Tokyo Metropolitan Hiroo Hospital , 2-34-10, Ebisu, Shibuya-ku, Tokyo 150-0013, Japan
                Author notes
                Corresponding author. Tel: +81-3-3444-1181, Fax: +81-3-3444-3196, Email: kujira1623@ 123456gmail.com

                Conflict of interest: None declared.

                Author information
                https://orcid.org/0000-0002-5011-9654
                https://orcid.org/0000-0001-6332-2355
                https://orcid.org/0000-0002-0291-9702
                Article
                ytac481
                10.1093/ehjcr/ytac481
                9856327
                36694876
                a08e0b9d-dc15-454d-a56a-9d6fbbc80cf3
                © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License ( https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                : 12 July 2022
                : 11 August 2022
                : 14 December 2022
                : 20 January 2023
                Page count
                Pages: 4
                Categories
                Case Report
                Electrophysiology
                AcademicSubjects/MED00200
                Ehjcr/4
                Ehjcr/23

                paroxysmal atrial fibrillation,case report,computed tomography,catheter ablation

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