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      Influence of Clonidine (Catapressan®-ST155) on the Muscle Blood Flow in the Legs of Hypertensive Patients (Antagonism of Tolazoline)

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          Using the Xenon133 local clearance technique, the influence of clonidine on the blood flow in the tibial anterior muscle of hypertensive patients was studied. Within 10 min after a single, slow intravenous injection of 0.15 mg clonidine, the mean blood pressure and the resting muscle blood flow decreased significantly, while the calculated resistance in this vascular bed tended to increase. During chronic oral administration of varying doses of clonidine, no significant changes were found in the muscle blood flow and vascular resistance at rest; however, determined after maximal ischemic exercise, the muscle blood flow was significantly decreased and the vascular resistance increased. Twenty mg tolazoline, injected intravenously in patients under chronic clonidine treatment, increase pulse rate and blood pressure but further decrease the resting muscle blood flow in the first 15 minutes after the injection.

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          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 7
          : 5
          : 296-311
          Department of Internal Medicine (Director: Prof. Dr. J. Vandenbroucke), Division of Cardiology (Director: Prof. Dr. J. V. Joossens), Section of Hypertension (Dr. A. Amery), University of Leuven, Leuven
          157844 Angiologica 1970;7:296–311
          © 1970 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 16


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