Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine.

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Abstract

BACKGROUND AND OBJECTIVE: An increasing trend in prescribing proton pump inhibitors (PPIs) inevitably increases the risk of unwanted drug-drug interactions (DDIs). The aim of this study was to uncover pharmacokinetic interactions between two PPIs-omeprazole and pantoprazole-and venlafaxine.

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Journal

Journal ID (iso-abbrev): Clin Pharmacokinet

Title: Clinical pharmacokinetics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1179-1926

ISSN (Print): 0312-5963

Publication date (Electronic): June 2018

Volume: 57

Issue: 6

Affiliations

[1 ] Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

[2 ] JARA, Translational Brain Medicine, Jülich, Germany.

[3 ] University Hospital of Psychiatry, Bern, Switzerland.

[4 ] Department of Psychiatry and Psychotherapy, Clinical Pharmacology, University of Regensburg, Regensburg, Germany.

[5 ] Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany.

[6 ] Department of Psychiatry and Psychotherapy, University Medical Center of Mainz, Mainz, Germany.

[7 ] Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Mainz, Germany.

[8 ] Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. m.paulzen@alexianer.de.

[9 ] JARA, Translational Brain Medicine, Jülich, Germany. m.paulzen@alexianer.de.

[10 ] Alexianer Hospital Aachen, Alexianergraben 33, 52062, Aachen, Germany. m.paulzen@alexianer.de.

Article

Publisher Item ID: 10.1007/s40262-017-0591-8

DOI: 10.1007/s40262-017-0591-8

PubMed ID: 28866861

SO-VID: a2009a1a-e8ab-4f40-863c-a7b2773c6877

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