MiR-214 protects MC3T3-E1 osteoblasts against H2O2-induced apoptosis by suppressing oxidative stress and targeting ATF4.

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Abstract

Fragility fracture is one of the common complications of osteoporosis. Elevated oxidative stress-induced apoptosis is thought to be one of the unfavorable factors to osteoblastic dysfunction, which increased the risk of bone fracture. However, the molecular mechanisms for oxidative stress-induced osteoblast cells apoptosis still need to be elucidated. This study aims to investigate the protective function of miR-214 in H2O2-induced apoptosis of MC3T3-E1 osteoblasts.

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Journal

Journal ID (iso-abbrev): Eur Rev Med Pharmacol Sci

Title: European review for medical and pharmacological sciences

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ISSN (Electronic): 2284-0729

ISSN (Print): 1128-3602

Publication date (Electronic): Nov 2017

Volume: 21

Issue: 21

Affiliations

[1 ] Department of Orthopedics, Ningbo No. 2 Hospital, Haishu District, Ningbo, Zhejiang, China. nbjoint@163.com.

Article

PubMed ID: 29164589

SO-VID: a26141c1-25ba-4a66-bf1b-b71c098d6837

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