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[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events
Myra S. Cocker ,
J. David Spence ,
Robert Hammond ,
Robert A. deKemp ,
Cheemun Lum ,
George Wells ,
Jordan Bernick ,
Andrew Hill ,
Sudhir Nagpal ,
Grant Stotts ,
Murad Alturkustani ,
Adebayo Adeeko ,
Yulia Yerofeyeva ,
Katey Rayner ,
Joan Peterson ,
Ali R. Khan ,
Ann C. Naidas ,
Linda Garrard ,
Martin J. Yaffe ,
Eugene Leung ,
Frank S. Prato ,
Jean-Claude Tardif ,
Rob S.B. Beanlands
November 2018
November 2018
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Abstract
[18F]-fluorodeoxyglucose (18FDG) uptake imaged with positron emission tomography (PET)
and computed tomography (CT) may serve as a biomarker of plaque inflammation. This
study evaluated the relationship between carotid plaque 18FDG uptake and a) intraplaque
expression of macrophage and macrophage-like cellular CD68 immunohistology; b) intraplaque
inflammatory burden using leukocyte-sensitive CD45 immunohistology; c) symptomatic
patient presentation; d) time from last cerebrovascular event.