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      Quantitative Histochemical Studies of the Hypothalamus. Dehydrogenase Enzymes during the Estrous Cycle

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          Abstract

          Three enzymes selected as representative of major metabolic pathways (malic dehydrogenase, of the citric acid cycle, lactic dehydrogenase, of glycolysis and glucose-6-phosphate dehydrogenase, of the pentose pathway) were measured by quantitative histochemical methods in individual hypothalamic nuclei during the 5-day estrous cycle of adult rats. Malic dehydrogenase increases significantly from low proestrous levels to a peak at estrus and then declines during diestrus in the following nuclei and areas of the anterior hypothalamus: medial and lateral preoptic, suprachiasmatic, supraoptic, and anterior. Significant peaks of lactic dehydrogenase occur more often during diestrus-3 in hypothalamic nuclei of the middle and posterior hypothalamus. Glucose-6-ρhosphate dehydrogenase has a biphasic pattern with peaks usually occurring during the diestrous period.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          25 March 2008
          : 22
          : 2
          : 117-126
          Affiliations
          Department of Psychiatry, Washington University School of Medicine, St. Louis, Mo.
          Article
          122617 Neuroendocrinology 1976;22:117–126
          10.1159/000122617
          1036242
          © 1976 S. Karger AG, Basel

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          Pages: 10
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