Bioactive secondary metabolites from an endophytic fungus Phoma sp. PF2 derived from Artemisia princeps Pamp.

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Abstract

Two new isochromanone derivatives, (3S,4S)-3,8-dihydroxy-6-methoxy-3,4,5-trimethylisochroman-1-one (1) and methyl (S)-8-hydroxy-6-methoxy-5-methyl-4a-(3-oxobutan-2-yl)benzoate (2), together with six known compounds (3‒8) were isolated from the cultures of an endophytic fungus Phoma sp. PF2 obtained from Artemisia princeps. The chemical structures of the isolated compounds were elucidated by interpretation of spectroscopic data (1D, 2D NMR, HRESIMS, and CD) and calculation of ECD. All the isolated compounds (1‒8) showed moderate inhibitory activities on nitric oxide levels in lipopolysaccharide-induced RAW264.7 machrophage cells.

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Journal

Journal ID (iso-abbrev): J Antibiot (Tokyo)

Title: The Journal of antibiotics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1881-1469

ISSN (Print): 0021-8820

Publication date (Electronic): March 2019

Volume: 72

Issue: 3

Affiliations

[1 ] College of Pharmacy and Innovative Drug Center, Duksung Women's University, Seoul, 01369, Republic of Korea.

[2 ] College of Korean Medicine, Gachon University, Seongnam, 13120, Republic of Korea.

[3 ] College of Pharmacy and Innovative Drug Center, Duksung Women's University, Seoul, 01369, Republic of Korea. sangheeshim@duksung.ac.kr.

Article

Publisher Item ID: 10.1038/s41429-018-0131-2

DOI: 10.1038/s41429-018-0131-2

PubMed ID: 30542160

SO-VID: a5a56822-3a81-4652-a233-ad9865f3d428

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