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      Enzymatic Distribution Patterns of Rat Lenses and the Changes that Occur during Naphthalene Cataract Development

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          Abstract

          The topographic distribution of enzyme activities in normal rat lenses and their changes occurring during naphthalene cataract development were investigated. Cataract formation was documented by slit images according to the Scheimpflug principle. Before the onset of visible changes and after the development of early visible opacities, the animals were sacrificed, their lenses removed and biochemically analyzed. The lenses were divided reproducibly into 6 parts – the equatorial ring and 5 layers of central cylinders from the anterior to the posterior cortex. The enzyme activity spectra (AR, SDH, GR, GPX, PFK, ALD, GAP-DH, and LDH) showed region-related patterns, which could not be detected with analysis of the total lens. Image analysis of the first signs of opacity showed that changes in the activities of several enzymes correlate with density changes in the corresponding lens layers.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1992
          1992
          10 December 2009
          : 24
          : 2
          : 73-82
          Affiliations
          Department of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan
          Article
          267150 Ophthalmic Res 1992;24:73–82
          10.1159/000267150
          1608600
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Original Paper

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