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      Padrão de relacionamento entre nanociências, saúde e biologia: um levantamento histórico utilizando o programa Citespace Translated title: The pattern of relationships between nanosciences, health, and biology: a historical survey using Citespace

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          Abstract

          Traça um padrão de relacionamento entre nanociências, saúde e biologia para estabelecer um panorama histórico no campo das nanociências. Utilizou-se o banco de dados Web of Science, com levantamento inicial pelas palavras-chave nanoscience e nanotechnology e também de palavras relacionadas a biologia e saúde. A aplicação do programa Citespace permitiu visualizar o padrão de relacionamento entre os tópicos lançados na base de pesquisa, proporcionando identificação de momentos de explosão e de ruptura do tema. Os dados obtidos mostram que a relação entre essas áreas emerge a partir de 2006, estando a maioria relacionada a nanomedicina. Trabalhos sobre nanotoxicologia também aparecem de forma significativa, uma vez que essas duas áreas necessitam caminhar juntas.

          Translated abstract

          The article traces a pattern of relationships between nanosciences, health, and biology to provide a historical overview of the nanoscience field. Input data came from the Web of Science databank, through a search first based on the keywords ‘nanoscience' and ‘nanotechnology' and also the selection of words related to biology and health. Application of the Citespace program made it possible to visualize the pattern of relationships between topics in the research base, allowing identification of burst and centrality points on the subject. Data findings show that the relationship between these areas emerged in 2006, most of them related to nanomedicine. There are also a significant number of works on nanotoxicology, since these two areas necessarily come hand in hand.

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          Most cited references30

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          Mechanistic aspects of biosynthesis of silver nanoparticles by several Fusarium oxysporum strains

          Extracellular production of metal nanoparticles by several strains of the fungus Fusarium oxysporum was carried out. It was found that aqueous silver ions when exposed to several Fusarium oxysporum strains are reduced in solution, thereby leading to the formation of silver hydrosol. The silver nanoparticles were in the range of 20–50 nm in dimensions. The reduction of the metal ions occurs by a nitrate-dependent reductase and a shuttle quinone extracellular process. The potentialities of this nanotechnological design based in fugal biosynthesis of nanoparticles for several technical applications are important, including their high potential as antibacterial material.
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            Nanocrystal targeting in vivo.

            Inorganic nanostructures that interface with biological systems have recently attracted widespread interest in biology and medicine. Nanoparticles are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery). Critical issues for successful nanoparticle delivery include the ability to target specific tissues and cell types and escape from the biological particulate filter known as the reticuloendothelial system. We set out to explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots). Qdots are small (<10 nm) inorganic nanocrystals that possess unique luminescent properties; their fluorescence emission is stable and tuned by varying the particle size or composition. We show that ZnS-capped CdSe qdots coated with a lung-targeting peptide accumulate in the lungs of mice after i.v. injection, whereas two other peptides specifically direct qdots to blood vessels or lymphatic vessels in tumors. We also show that adding polyethylene glycol to the qdot coating prevents nonselective accumulation of qdots in reticuloendothelial tissues. These results encourage the construction of more complex nanostructures with capabilities such as disease sensing and drug delivery.
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              SEMIPERMEABLE MICROCAPSULES.

              T. Chang (1964)
              Simple methods have been developed for encapsulating aqueous solutions of protein within polymer membranes. Stable microcapsules 1 to 100 micro in diameter, with semipermeable membranes, can be made by depositing polymer around emulsified aqueous droplets, either by interfacial coacervation or by interfacial polycondensation. Aqueous suspensions of enzyme-loaded microcapsules act well on small-molecular substrates both in vitro and in vivo.
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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Journal
                hcsm
                História, Ciências, Saúde-Manguinhos
                Hist. cienc. saude-Manguinhos
                Casa de Oswaldo Cruz, Fundação Oswaldo Cruz (Rio de Janeiro )
                1678-4758
                December 2013
                : 20
                : 4
                : 1657-1670
                Affiliations
                [1 ] Universidade Federal do Rio Grande Brazil
                [2 ] Universidade Federal do Rio Grande Brazil
                [3 ] Universidade Federal do Rio Grande Brazil
                Article
                S0104-59702013000401657
                10.1590/S0104-59702013005000008
                23827968
                a63519d6-0665-428c-9eb9-99a8145b99ba

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=0104-5970&lng=en
                Categories
                HISTORY & PHILOSOPHY OF SCIENCE

                Philosophy of science
                nanosciences,biology,health,Citespace,pattern of relationships,nanociências,biologia,saúde,padrão de relacionamento

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