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      Fracture liaison service utilising an emergency department information system to identify patients effectively reduce re‐fracture rate is cost‐effective and cost saving in Western Australia

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          Abstract

          Objectives

          To assess the benefits of the Emergency Department Information System (EDIS)‐linked fracture liaison service (FLS).

          Methods

          Patients identified through EDIS were invited to attend an FLS at the intervention hospital, the Sir Charles Gairdner Hospital (SCGS‐FLS). The intervention group was compared to usual care. Retrospective control (RC) at this hospital determined historical fracture risk (SCGH‐RC). Prospective control (PC) was from a comparator, Fremantle Hospital (FH‐PC). The main outcome measures were cost‐effectiveness from a health system perspective and quality of life by EuroQOL (EQ‐5D). Bottom‐up cost of medical care, against the cost of managing recurrent fracture (weighted basket), was determined from the literature and 2013/14 Australian Refined Diagnosis Related Groups (AR‐DRG) prices. Mean incremental cost‐effectiveness ratios were simulated from 5000 bootstrap iterations. Cost‐effectiveness acceptability curves were generated.

          Results

          The SCGH‐FLS program reduced absolute re‐fracture rates versus control cohorts (9.2–10.2%), producing an estimated cost saving of AUD$750,168–AUD$810,400 per 1000 patient‐years in the first year. Between‐groups QALYs differed with worse outcomes in both control groups ( p < 0.001).

          The SCGH‐FLS compared with SCGH‐RC and FH‐PC had a mean incremental cost of $8721 (95% CI −$1218, $35,044) and $8974 (95% CI −$26,701, $69,929), respectively, per 1% reduction in 12‐month recurrent fracture risk. The SCGH‐FLS compared with SCGH‐RC and FH‐PC had a mean incremental cost of $292 (95% CI −$3588, $3380) and −$261 (95% CI −$1521, $471) per EQ‐5D QALY gained at 12 months respectively. With societal willingness to pay of $16,000, recurrent fracture is reduced by 1% in >80% of patients.

          Conclusions

          This simple and easy model of identification and intervention demonstrated efficacy in reducing rates of recurrent fracture and was cost‐effective and potentially cost saving.

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          Most cited references27

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          Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.

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            Pathogenesis of osteoporosis: concepts, conflicts, and prospects.

            Osteoporosis is a disorder in which loss of bone strength leads to fragility fractures. This review examines the fundamental pathogenetic mechanisms underlying this disorder, which include: (a) failure to achieve a skeleton of optimal strength during growth and development; (b) excessive bone resorption resulting in loss of bone mass and disruption of architecture; and (c) failure to replace lost bone due to defects in bone formation. Estrogen deficiency is known to play a critical role in the development of osteoporosis, while calcium and vitamin D deficiencies and secondary hyperparathyroidism also contribute. There are multiple mechanisms underlying the regulation of bone remodeling, and these involve not only the osteoblastic and osteoclastic cell lineages but also other marrow cells, in addition to the interaction of systemic hormones, local cytokines, growth factors, and transcription factors. Polymorphisms of a large number of genes have been associated with differences in bone mass and fragility. It is now possible to diagnose osteoporosis, assess fracture risk, and reduce that risk with antiresorptive or other available therapies. However, new and more effective approaches are likely to emerge from a better understanding of the regulators of bone cell function.
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              Osteoporosis: impact on health and economics.

              Osteoporosis is a major public health problem through associated fragility fractures. The most common sites of fracture are the hip, spine and wrist, and these have an enormous health and economic impact. All fractures result in some degree of morbidity, but fractures at the hip are associated with the worst outcomes. The worldwide direct and indirect annual costs of hip fracture in 1990 were estimated at US$34.8 billion, and are expected to increase substantially over the next 50 years. Fracture incidence varies between populations, and is set to increase over coming decades as the global population becomes more elderly. This effect will be particularly marked in the developing world, which is additionally assuming more-westernized lifestyles that predispose to increased fracture risk. Strategies to target those at high risk of fracture have been developed, but preventative measures at the public health level are also urgently needed to reduce the burden of this devastating disease.
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                Author and article information

                Contributors
                charles.inderjeeth@health.wa.gov.au
                Journal
                Australas J Ageing
                Australas J Ageing
                10.1111/(ISSN)1741-6612
                AJAG
                Australasian Journal on Ageing
                John Wiley and Sons Inc. (Hoboken )
                1440-6381
                1741-6612
                10 July 2022
                September 2022
                : 41
                : 3 ( doiID: 10.1111/ajag.v41.3 )
                : e266-e275
                Affiliations
                [ 1 ] Department of Rehabilitation & Aged Care Sir Charles Gairdner and Osborne Park Hospital Group Nedlands Western Australia Australia
                [ 2 ] School of Medicine & Pharmacology The University of Western Australia Crawley Western Australia Australia
                [ 3 ] School of Allied Health The University of Western Australia Crawley Western Australia Australia
                [ 4 ] School of Physiotherapy & Exercise Science Curtin University Perth Western Australia Australia
                [ 5 ] Medical Education Unit Western Australia Country Health Service Perth Western Australia Australia
                Author notes
                [*] [* ] Correspondence

                Charles A. Inderjeeth, Department of Rehabilitation & Aged Care, Sir Charles Gairdner Hospital, Hospital Ave, Nedlands, WA 6009, Australia.

                Email: charles.inderjeeth@ 123456health.wa.gov.au

                Author information
                https://orcid.org/0000-0003-0535-963X
                Article
                AJAG13107 AAJA-2021-361.R2
                10.1111/ajag.13107
                9545318
                35811331
                a65a8ee5-4e6d-4e1f-a92a-07a7589f6a0b
                © 2022 The Authors. Australasian Journal on Ageing published by John Wiley & Sons Australia, Ltd on behalf of AJA Inc’.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 03 May 2022
                : 13 January 2022
                : 11 May 2022
                Page count
                Figures: 3, Tables: 2, Pages: 10, Words: 4560
                Funding
                Funded by: a PhD Scholarship in Memory of John Donald Stewart awarded by the Arthritis and Osteoporosis Foundation of Western Australia
                Funded by: an NHMRC TRIP Fellowship
                Award ID: #1132548
                Funded by: State Health Research Advisory Council , doi 10.13039/501100000961;
                Award ID: TRIAL No: 2012‐142
                Funded by: Department of Health , doi 10.13039/501100003921;
                Categories
                Research Article
                Research Articles
                Custom metadata
                2.0
                September 2022
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.2.0 mode:remove_FC converted:07.10.2022

                analyses,cost benefit,fractures,health care economics and organizations,integrated health care systems,osteoporotic,prevention,secondary

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