The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study

Author(s): Xiaolei Chen ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Huangcong Shi ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Cheng Li ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Wanxia Zhong ⁸ ^, ⁹ , Linlin Cui ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, ⁷ , Wenjun Zhang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Ling Geng ¹ , Kuona Hu ¹ , Mei Fang ¹ , Daimin Wei ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Junhao Yan ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ , Yun Sun ⁸ ^, ⁹ ^, , Keliang Wu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, , Han Zhao ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, , Zi-Jiang Chen ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, ⁸ ^, ⁹ ^,

Publication date (Electronic): 9 February 2023

Journal: Science China. Life Sciences

Publisher: Science China Press

Read this article at

ScienceOpenPublisher PMC

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Electronic supplementary material Supplementary material, approximately 326 KB.

Related collections

Most cited references 10

Record: found
Abstract: found
Article: found

Is Open Access

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang … (2020)

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.

0 comments Cited 10152 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

SARS-CoV-2 infection risk assessment in the endometrium: Viral infection-related gene expression across the menstrual cycle

Ismael Henarejos-Castillo, Patricia Sebastián-León, Almudena Devesa-Peiro … (2020)

STRUCTURED ABSTRACT Objective To determine susceptibility of the endometrium to infection by—and thereby potential damage from—SARS-CoV-2. Design Analysis of SARS-Cov-2 infection-related gene expression from endometrial transcriptomic datasets. Setting Infertility research department affiliated with a public hospital. Patient(s) Gene expression data from five studies in 112 patients with normal endometrium collected throughout the menstrual cycle. Intervention(s) None. Main outcome measure(s) Gene expression and correlation between viral infectivity genes and age throughout the menstrual cycle. Result(s) Gene expression was high for TMPRSS4, CTSL, CTSB, FURIN, MX1, and BSG; medium for TMPRSS2; and low for ACE2. ACE2, TMPRSS4, CTSB, CTSL, and MX1 expression increased toward the window of implantation. TMPRSS4 expression was positively correlated with ACE2, CTSB, CTSL, MX1, and FURIN during several cycle phases; TMPRSS2 was not significantly altered across the cycle. ACE2, TMPRSS4, CTSB, CTSL, BSG and MX1 expression increased with age, especially in early phases of the cycle. Conclusion(s) Endometrial tissue is likely safe from SARS-CoV-2 cell entry based on ACE2 and TMPRSS2 expression, but susceptibility increases with age. Further, TMPRSS4, along with BSG-mediated viral entry into cells, could imply a susceptible environment for SARS-CoV-2 entry via different mechanisms. Additional studies are warranted to determine the true risk of endometrial infection by SARS-CoV-2 and implications for fertility treatments.

0 comments Cited 53 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Influence of COVID-19 pandemic on the psychological status of infertile couples

Veronica Esposito, Erika Rania, Daniela Lico … (2020)

Highlights • No data are available to the distress of infertile couples during COVID-19. • Stop performing ART treatments during COVID-19 contributed to increase anxiety. • The psychological impact was more severe for women than for men. • Psychological impact of COVID-19 in infertility couple should not be underestimated.

0 comments Cited 34 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Yun Sun: syun163@163.com

Keliang Wu: wukeliang_527@163.com

Han Zhao: hanzh80@sdu.edu.cn

Zi-Jiang Chen: chenzijiang@hotmail.com

Journal

Journal ID (nlm-ta): Sci China Life Sci

Journal ID (iso-abbrev): Sci China Life Sci

Title: Science China. Life Sciences

Publisher: Science China Press (Beijing )

ISSN (Print): 1674-7305

ISSN (Electronic): 1869-1889

Publication date (Electronic): 9 February 2023

Pages: 1-4

Affiliations

[1 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, Center for Reproductive Medicine, , Shandong University, ; Jinan, 250012 China

[2 ]GRID grid.506261.6, ISNI 0000 0001 0706 7839, Research Unit of Gametogenesis and Health of ART-Offspring, , Chinese Academy of Medical Sciences, ; Jinan, 250012 China

[3 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, Key Laboratory of Reproductive Endocrinology of Ministry of Education, , Shandong University, ; Jinan, 250012 China

[4 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, Shandong Key Laboratory of Reproductive Medicine, ; Jinan, 250012 China

[5 ]Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, 250012 China

[6 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, National Research Center of Assisted Reproductive Technology and Reproductive Genetics, , Shandong University, ; Jinan, 250012 China

[7 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, Center for Reproductive Medicine, The Second Hospital, Cheeloo College of Medicine, , Shandong University, ; Jinan, 250012 China

[8 ]GRID grid.16821.3c, ISNI 0000 0004 0368 8293, Center for reproductive medicine, Ren Ji Hospital, School of Medicine, , Shanghai Jiao Tong University, ; Shanghai, 200127 China

[9 ]GRID grid.452927.f, ISNI 0000 0000 9684 550X, Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, ; Shanghai, 200127 China

Article

Publisher ID: 2291

DOI: 10.1007/s11427-023-2291-0

PMC ID: 9933004

PubMed ID: 36795183

SO-VID: a663b10d-6663-4921-9160-90820fabe513

License:

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

History

Date received : 16 January 2023

Date accepted : 6 February 2023

Comments

Comment on this article

scite_

Cited by 3

See all cited by

Most referenced authors 323

See all reference authors

- Version 1

The effect of SARS-CoV-2 infection on human embryo early development: a multicenter prospective cohort study

Read this article at

Abstract

Related collections

Novel Coronavirus Disease COVID-19

Most cited references 10

A pneumonia outbreak associated with a new coronavirus of probable bat origin

SARS-CoV-2 infection risk assessment in the endometrium: Viral infection-related gene expression across the menstrual cycle

Influence of COVID-19 pandemic on the psychological status of infertile couples

Author and article information

Contributors

Journal

Affiliations

Article

History

Categories

Comments

Comment on this article

Similar content 2,055

Cited by 3

Most referenced authors 323