Raphael J. Eberle:
ORCID: https://orcid.org/0000-0002-8763-3884
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: Writing – original draft
Danilo S. Olivier:
ORCID: https://orcid.org/0000-0003-1269-3783
Role: InvestigationRole: SoftwareRole: Validation
Carolina C. Pacca: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Validation
Clarita M. S. Avilla: Role: InvestigationRole: Methodology
Mauricio L. Nogueira: Role: Formal analysisRole: Resources
Marcos S. Amaral:
ORCID: https://orcid.org/0000-0001-8101-6933
Role: InvestigationRole: SoftwareRole: Validation
Dieter Willbold: Role: ResourcesRole: Writing – review & editing
Raghuvir K. Arni: Role: ResourcesRole: Writing – review & editing
Monika A. Coronado: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
SupervisionRole: ValidationRole: Writing – review & editing
Bryan Mounce: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
4
March
2021
Publication date Collection: 2021
Volume: 16
Issue: 3
Electronic Location Identifier: e0246319
Affiliations
[1
]
Multiuser Center for Biomolecular Innovation, Departament of Physics, Instituto de
Biociências Letras e Ciências Exatas (Ibilce), Universidade Estadual Paulista (UNESP),
São Jose do Rio Preto, SP, Brazil
[2
]
Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum
Jülich, Jülich, Germany
[3
]
Federal University of Tocantins, Araguaína, TO, Brazil
[4
]
Instituto de Biociências Letras e Ciências Exatas (Ibilce), Universidade Estadual
Paulista (UNESP), São Jose do Rio Preto, SP, Brazil
[5
]
FACERES Medical School, São José do Rio Preto, Brazil
[6
]
Faculdade de Medicina de São José do Rio Preto–FAMERP, São José do Rio Preto, Brazil
[7
]
Institute of Physics, Federal University of Mato Grosso do Sul, Campo Grande, MS,
Brazil
[8
]
Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße,
Düsseldorf, Germany
[9
]
JuStruct: Jülich Centre for Structural Biology, Forchungszentrum Jülich, Jülich, Germany
Loyola University Chicago, UNITED STATES
Author notes
Competing Interests: The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PONE-D-20-32447
DOI: 10.1371/journal.pone.0246319
PMC ID: 7932080
PubMed ID: 33661906
SO-VID: a6d91d27-bc15-4bc2-9cdf-502b78bd915b
Copyright © © 2021 Eberle et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
Award ID: 435913/2016-6
Award Recipient
:
Raghuvir K. Arni
Funded by: funder-id http://dx.doi.org/10.13039/501100003593, Conselho Nacional de Desenvolvimento Científico e Tecnológico;
Award ID: 401270/2014-9
Award Recipient
:
Raghuvir K. Arni
Funded by: funder-id http://dx.doi.org/10.13039/501100003593, Conselho Nacional de Desenvolvimento Científico e Tecnológico;
Award ID: 307338/2014-2
Award Recipient
:
Raghuvir K. Arni
Funded by: funder-id http://dx.doi.org/10.13039/501100001807, Fundação de Amparo à Pesquisa do Estado de São Paulo;
Award ID: 2016/12904-0
Award Recipient
:
Monika A. Coronado
Funded by: funder-id http://dx.doi.org/10.13039/501100001807, Fundação de Amparo à Pesquisa do Estado de São Paulo;
Award ID: 2018/12659-0
Award Recipient
:
Monika A. Coronado
Funded by: funder-id http://dx.doi.org/10.13039/501100001807, Fundação de Amparo à Pesquisa do Estado de São Paulo;
Award ID: 2018/07572-3
Award Recipient
:
ORCID: https://orcid.org/0000-0002-8763-3884
Raphael J. Eberle
Funded by: funder-id http://dx.doi.org/10.13039/501100001807, Fundação de Amparo à Pesquisa do Estado de São Paulo;
Award ID: 2019/05614-3
Award Recipient
:
ORCID: https://orcid.org/0000-0002-8763-3884
Raphael J. Eberle
Funded by: funder-id http://dx.doi.org/10.13039/501100005672, Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de
Mato Grosso do Sul;
Award ID: 23/200.307/2014
Award Recipient
:
ORCID: https://orcid.org/0000-0001-8101-6933
Marcos S. Amaral
The study was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico
(435913/2016-6, 401270/2014-9, 307338/2014-2) received by RA. Fundação de Amparo à
Pesquisa do Estado de São Paulo (2016/12904-0, 2018/12659-0, 2018/07572-3, 2019/05614-3)
by RE and MC. Ciência e Tecnologia do Estado de Mato Grosso do Sul (23/200.307/2014)
by MA. The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Togaviruses
Subject:
Alphaviruses
Subject:
Chikungunya Virus
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Proteases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
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Proteins
Subject:
Enzymes
Subject:
Proteases
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Zika Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Zika Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Zika Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Zika Virus
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Biochemical Simulations
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Biochemical Simulations
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
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Tropical Diseases
Subject:
Neglected Tropical Diseases
Subject:
Chikungunya Infection
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Chikungunya Infection
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Dengue Virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Dengue Virus
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Dengue Virus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Flaviviruses
Subject:
Dengue Virus
Subject:
Research and Analysis Methods
Subject:
Spectrum Analysis Techniques
Subject:
Fluorescence Spectroscopy
Subject:
Research and analysis methods
Subject:
Bioassays and physiological analysis
Subject:
Biochemical analysis
Subject:
Colorimetric assays
Subject:
MTT assay
Subject:
Research and analysis methods
Subject:
Bioassays and physiological analysis
Subject:
Biochemical analysis
Subject:
Enzyme assays
Subject:
MTT assay
