Blog
About

16
views
0
recommends
+1 Recommend
1 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Endeavor to elucidate the mechanisms of skin fibrosis in recessive dystrophic epidermolysis bullosa

      Impact

      Science Impact, Ltd.

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Epidermolysis bullosa (EB) is a group of genetic skin blistering diseases. Clinically, individuals with EB are characterized by fragile skin and blister formations induced by minor trauma. Dystrophic epidermolysis bullosa (DEB) is one of the four major subtypes of EB, affecting around 25 per cent of people affected by EB, and can range from mild to severe. In mild cases blistering can mainly affect the hands, feet, knees and elbows, whereas severe cases often involve widespread blistering that can cause severe fibrosis such as adhesion of digits, aggressive cutaneous squamous cell carcinoma, and other medical problems. Expert dermatologist Dr Eijiro Akasaka, who is based at the Department of Dermatology, Hirosaki University Graduate School of Medicine in Japan, explains that the disorder is caused by mutations in the gene encoding type VII collagen, COL7A1, and is inherited in both autosomal dominant and recessive trait. 'The recessive inheritable types (RDEB) can lead to disability and reduced life expectancy,' he explains. 'Currently, there is no safe and effective treatment for RDEB but we are striving to develop one.'

          Related collections

          Author and article information

          Journal
          Impact
          impact
          Science Impact, Ltd.
          2398-7073
          August 02 2019
          August 02 2019
          : 2019
          : 7
          : 72-74
          Article
          10.21820/23987073.2019.7.72
          © 2019

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          Earth & Environmental sciences, Medicine, Computer science, Agriculture, Engineering

          Comments

          Comment on this article