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      Mode of action of phleomycin on Bacillus subtilis.

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      Journal of bacteriology

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          Abstract

          Phleomycin appears to act on the cell wall and membrane to induce the release of membrane-associated deoxyribonucleic acid (DNA) and the degradation of the DNA. Degradation occurs in a series of energy-requiring endonuclease and exonuclease reactions. These produce, first, single-strand breaks, then double-strand breaks, and finally almost complete solubilization of the cellular DNA. The in vivo inhibition of DNA synthesis by phleomycin is probably a secondary effect caused by the destruction of template DNA.

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          Author and article information

          Journal
          J. Bacteriol.
          Journal of bacteriology
          0021-9193
          0021-9193
          Aug 1972
          : 111
          : 2
          Article
          251321
          4626504

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