Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial.

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Abstract

Morphine may decrease the intensity of chronic breathlessness but data from a large randomised controlled trial (RCT) are lacking. This first, large, parallel-group trial aimed to test the efficacy and safety of regular, low-dose, sustained-release (SR) morphine compared with placebo for chronic breathlessness.

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Journal

Journal ID (iso-abbrev): Thorax

Title: Thorax

Publisher: BMJ

ISSN (Electronic): 1468-3296

ISSN (Print): 0040-6376

Publication date (Electronic): January 2020

Volume: 75

Issue: 1

Affiliations

[1 ] IMPACCT, Faculty of Heath, University of Technology Sydney, Sydney, New South Wales, Australia david.currow@uts.edu.au.

[2 ] College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.

[3 ] McCloud Consulting Group, Sydney, New South Wales, Australia.

[4 ] IMPACCT, Faculty of Heath, University of Technology Sydney, Sydney, New South Wales, Australia.

[5 ] Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia.

[6 ] University of Melbourne, Melbourne, Victoria, Australia.

[7 ] Northern Sydney Local Health District, Saint Leonards, New South Wales, Australia.

[8 ] Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia.

[9 ] Deakin Health Economics, Deakin University Faculty of Health, Burwood, Victoria, Australia.

[10 ] Department of Clinical Sciences, Division of Respiratory Medicine & Allergology, Lund University, Lund, Sweden.

Article

Publisher Item ID: thoraxjnl-2019-213681

DOI: 10.1136/thoraxjnl-2019-213681

PubMed ID: 31558624

SO-VID: a7839e68-0fd8-4f2c-9b56-df63e119386f

History

Keywords: symptom relief,randomised controlled trial,placebo study,sustained release morphine,chronic breathlessness

Data availability:

Keywords: symptom relief, randomised controlled trial, placebo study, sustained release morphine, chronic breathlessness

Regular, sustained-release morphine for chronic breathlessness: a multicentre, double-blind, randomised, placebo-controlled trial.

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